Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 13/20 | 0.45 |
| ▸ | CTSS | P25774 | 9/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.45 |
| ▸ | CTSV | O60911 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591709 | 0.93 | CTSK (0.46) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL6591711 | 0.93 | CTSK (0.46) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL4766723 | 0.90 | CTSK (0.46) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL4766721 | 0.90 | CTSK (0.46) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL6404263 | 0.89 | CTSK (0.50) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL4768953 | 0.89 | CTSK (0.45) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL4768959 | 0.89 | CTSK (0.45) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL4762063 | 0.88 | TAS1R3 (0.47) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL4762061 | 0.88 | TAS1R3 (0.47) | CTSKTAS1R3TAS1R1CTSLCTSS | |
| SCHEMBL4762139 | 0.87 | CTSK (0.46) | CTSKTAS1R3TAS1R1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |