Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.32 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 4/20 | 0.34 |
| ▸ | FPR3 | P25089 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4823389 | 1.00 | SYK (0.38) | SYKFDFT1FPR2FPR3ALDH1A1 | |
| SCHEMBL4670843 | 0.88 | SLC6A2 (0.37) | SYKFDFT1FPR2FPR3SLC6A2 | |
| Fumaric Acid SCHEMBL4819665 | 0.76 | NR4A1 (0.33) | — | |
| Fumaric Acid SCHEMBL4819673 | 0.76 | NR4A1 (0.33) | — | |
| SCHEMBL4669013 | 0.73 | SYK (0.39) | SYKFPR2FPR3HDAC1HDAC8 | |
| SCHEMBL4821917 | 0.72 | FDFT1 (0.36) | FDFT1FPR2FPR3ALDH1A1SLC6A2 | |
| SCHEMBL5302085 | 0.72 | KDM1A (0.30) | SYKFPR2 | |
| SCHEMBL4821912 | 0.72 | FPR2 (0.39) | FDFT1FPR2FPR3ALDH1A1SLC6A2 | |
| SCHEMBL4670847 | 0.72 | TNF (0.38) | SYKMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4821983 | 0.72 | SYK (0.39) | SYKFPR2FPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388022-B2 | Polysubstituted 1,1-pyridylaminocyclopropanamine compounds | LES LABORATOIRES SERVIER (FR) | 2008-06-17 | — | — | US | disclosed |
| US-20070027192-A1 | Polysubstituted 1,1-pyridylamioncyclopropanamine compounds | LES LABORATOIRES SERVIER (FR) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027192-A1 | Polysubstituted 1,1-pyridylamioncyclopropanamine compounds | CHRM1, CHRM2, CHRM3 | SLC6A2 479/4885SLC6A4 541/4885KMT2A 2287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.