Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 8/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823815 | 1.00 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL4811499 | 0.86 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL4806577 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL4806588 | 0.86 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL4811506 | 0.86 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL4813189 | 0.77 | KDM4E (0.43) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL4813185 | 0.77 | KDM4E (0.43) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL548079 | 0.68 | CA12 (0.53) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL22215903 | 0.67 | MAPT (0.63) | ADRA2AADRA2BADRA2CMEN1KMT2A | |
| SCHEMBL577828 | 0.67 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320986-B2 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBOTT LABORTORIES (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | ABBVIE INC. | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259904-A1 | Fused tri and tetra-cyclic pyrazole kinase inhibitors | TK1, MAP3K19, MAP3K20 | ADRA2A 4476/4885ADRA2B 4097/4885ADRA2C 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.