Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.32 |
| ▸ | ADH1A | P07327 | 1/20 | 0.32 |
| ▸ | ADH7 | P40394 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.31 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | DUT | P33316 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20500252 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL5073223 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL20500262 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL4333525 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL4821411 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL20500283 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL22664469 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL38662 | 0.98 | SMYD2 (0.38) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL641418 | 0.94 | SMYD2 (0.38) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL16705774 | 0.91 | HDAC1 (0.34) | SMYD2CYP3A4HTTSMN1; SMN2LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116410098-A | Preparation method for synthesizing alpha-aminoketone compound from fatty aldehyde and secondary amine | 西北工业大学 | 2023-07-11 | — | — | CN | claimed |
| CN-116396193-A | Method for preparing alpha-sulfonamido acetals from fatty aldehydes and sulfonamides | 西北工业大学 | 2023-07-07 | — | — | CN | claimed |
| US-20260132133-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC (US) | 2026-05-14 | — | — | US | disclosed |
| US-12415770-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | Emory University, Office of Technology Transfer (US) | 2025-09-16 | — | — | US | disclosed |
| EP-4516774-A2 | MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES | Emory University (US) | 2025-03-05 | — | — | EP | disclosed |
| EP-4511128-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | Kumquat Biosciences Inc. (US) | 2025-02-26 | — | — | EP | disclosed |
| US-12195465-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2025-01-14 | — | — | US | disclosed |
| CN-119095849-A | Macrocyclic heterocycles and uses thereof | 金橘生物科技公司 | 2024-12-06 | — | — | CN | disclosed |
| EP-3595652-B1 | MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) | UNIV EMORY (US) | 2024-12-04 | — | — | EP | disclosed |
| US-20240368066-A1 | MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES | EMORY UNIVERSITY | 2024-11-07 | — | — | US | disclosed |
| US-12065402-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | EMORY UNIVERSITY (US) | 2024-08-20 | — | — | US | disclosed |
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| US-20210047258-A1 | Modulators of Liver Receptor Homologue 1 (LRH-1) and Uses | EMORY UNIVERSITY | 2021-02-18 | — | — | US | disclosed |
| US-10843996-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | EMORY UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| CN-100562516-C | Amyloid-beta produces and the excretory inhibitor | DAIICHI SEIYAKU CO (JP) | 2009-11-25 | — | — | CN | disclosed |
| US-7399775-B2 | β-amyloid protein production/secretion inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-07-15 | — | — | US | disclosed |
| US-20070293495-A1 | BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |
| US-20050234109-A1 | to treat Alzheimer's disease,Down syndrome and the other diseases associated with amyloid deposition; thiomethane, sulfinylmethane or sulfonylmethane compounds; 5-Chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]-2-(4'-hydroxypiperidin-1'-yl)pyridine | DAIICHI PHARMACEUTICAL CO. LTD. (JP) | 2005-10-20 | — | — | US | disclosed |
| CN-1585746-A | Inhibitors of beta-amyloid production and secretion | DAIICHI SEIYAKU CO (JP) | 2005-02-23 | — | — | CN | disclosed |
| EP-1466898-A1 | BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368066-A1 | MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES | NR1H2, NR1H3, NR1H4 | SMYD2 1285/4885CYP3A4 2300/4885HTT 3051/4885 |
| US-12415770-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | NR1H2, NR1H3, NR1H4 | SMYD2 1285/4885CYP3A4 2300/4885HTT 3051/4885 |
| US-20260132133-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KRAS, HRAS, BCL6 | SMYD2 3599/4885CYP3A4 4547/4885HTT 3433/4885 |
| US-12195465-B2 | Macrocyclic heterocycles and uses thereof | HRAS, KRAS, TP53 | SMYD2 2501/4885CYP3A4 4634/4885HTT 476/4885 |
| US-12065402-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | NR1H2, NR1H3, NR1H4 | SMYD2 1285/4885CYP3A4 2300/4885HTT 3051/4885 |
| US-10843996-B2 | Modulators of liver receptor homologue 1 (LRH-1) and uses | NR1H2, NR1H3, NR1H4 | SMYD2 1285/4885CYP3A4 2300/4885HTT 3051/4885 |
| US-20050234109-A1 | to treat Alzheimer's disease,Down syndrome and the other diseases associated with amyloid deposition; thiomethane, sulfinylmethane or sulfonylmethane compounds; 5-Chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]-2-(4'-hydroxypiperidin-1'-yl)pyridine | APP, PSEN1, PSEN2 | SMYD2 2291/4885CYP3A4 3053/4885HTT 8/4885 |
| US-20210047258-A1 | Modulators of Liver Receptor Homologue 1 (LRH-1) and Uses | NR1H2, NR1H3, NR1H4 | SMYD2 1285/4885CYP3A4 2300/4885HTT 3051/4885 |
| US-20070293495-A1 | BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS | APP, IAPP, BACE1 | SMYD2 4482/4885CYP3A4 2566/4885HTT 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.