Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.32 |
| ▸ | ADH1A | P07327 | 1/20 | 0.32 |
| ▸ | ADH7 | P40394 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.31 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | DUT | P33316 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20500252 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL5073223 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL20500262 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL4824010 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL4821411 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL20500283 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL22664469 | 1.00 | SMYD2 (0.37) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL38662 | 0.98 | SMYD2 (0.38) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL641418 | 0.94 | SMYD2 (0.38) | SMYD2CYP3A4HTTSMN1; SMN2ADH1B | |
| SCHEMBL16705774 | 0.91 | HDAC1 (0.34) | SMYD2CYP3A4HTTSMN1; SMN2LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030176398-A1 | Prodrugs of GABA analogs, compositions and uses thereof | HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT | 2003-09-18 | — | — | US | claimed |
| WO-2009133686-A1 | MEDICAMENTS FOR TREATING ALZHEIMER'S DISEASE | 有限会社アンティアンティ (JP) | 2009-11-05 | — | — | WO | disclosed |
| EP-2085087-A1 | Prodrugs of gaba analogs, compositions and uses thereof | Xenoport, Inc. (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1902714-A1 | Prodrugs of gaba analogs, compositions and uses thereof | Xenoport, Inc. (US) | 2008-03-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176398-A1 | Prodrugs of GABA analogs, compositions and uses thereof | GABRB1, GABRB2, GABRB3 | SMYD2 4034/4885CYP3A4 88/4885HTT 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.