Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 2/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2134783 | 0.74 | ALDH1A1 (0.39) | ALDH1A1GAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL5754678 | 0.74 | HSP90AA1 (0.38) | ALDH1A1HTTKDM4ESMN1; SMN2MAPT | |
| SCHEMBL15534139 | 0.72 | ALDH1A1 (0.51) | ALDH1A1GAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL7253389 | 0.71 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4ESMN1; SMN2HSP90AA1 | |
| SCHEMBL20521619 | 0.71 | ALDH1A1 (0.38) | ALDH1A1GAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL24970292 | 0.70 | ALDH1A1 (0.45) | ALDH1A1GAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL20448220 | 0.70 | SCN9A (0.38) | ALDH1A1GAAKDM4ESMN1; SMN2MAPT | |
| SCHEMBL20448208 | 0.70 | AR (0.38) | ALDH1A1GAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL24054000 | 0.69 | ALDH1A1 (0.41) | ALDH1A1GAAHTTKDM4ESMN1; SMN2 | |
| SCHEMBL14785028 | 0.69 | CDK2 (0.50) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442698-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1654238-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005009978-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| US-20050026914-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026914-A1 | Substituted heterocyclic compounds and methods of use | NFATC1, ICOS, BET1 | ALDH1A1 370/4885GAA 3390/4885HTT 3316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.