Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | FGB | P02675 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162223 | 0.78 | RPS6KA5 (0.35) | ALDH1A1SMN1; SMN2KDM4EMAPTRPS6KA5 | |
| SCHEMBL4824253 | 0.74 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2KDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL30936977 | 0.69 | RPS6KA5 (0.36) | ALDH1A1SMN1; SMN2KDM4EMAPTMAPK1 | |
| SCHEMBL3334777 | 0.68 | RPS6KA5 (0.44) | ALDH1A1SMN1; SMN2KDM4EADORA2AADORA1 | |
| SCHEMBL10486228 | 0.66 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2KDM4EADORA2AMAPT | |
| SCHEMBL30919916 | 0.66 | ADORA1 (0.50) | ALDH1A1SMN1; SMN2KDM4EADORA2AADORA1 | |
| SCHEMBL30919634 | 0.66 | ADORA1 (0.50) | ALDH1A1SMN1; SMN2KDM4EADORA2AADORA1 | |
| SCHEMBL27264298 | 0.66 | ADORA1 (0.50) | ALDH1A1SMN1; SMN2KDM4EADORA2AADORA1 | |
| SCHEMBL2093666 | 0.66 | CYP1A1 (0.41) | ALDH1A1SMN1; SMN2ADORA2AMAPTMAPK1 | |
| SCHEMBL5754678 | 0.66 | HSP90AA1 (0.38) | ALDH1A1SMN1; SMN2KDM4EADORA2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165332-A1 | SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2012-06-28 | — | — | US | disclosed |
| EP-2443095-A1 | SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS | Cellzome Limited (GB) | 2012-04-25 | — | — | EP | disclosed |
| WO-2010146132-A1 | SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165332-A1 | SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS | ZAP70, LCK, SYK | ALDH1A1 3211/4885SMN1; SMN2 2743/4885KDM4E 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.