Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4824163 | 0.81 | AKR1C3 (0.43) | MAPK1L3MBTL1ALDH1A1AKR1C3POLB | |
| SCHEMBL1328014 | 0.80 | HTR1A (0.39) | CD274POLB | |
| SCHEMBL2139611 | 0.79 | SMN1; SMN2 (0.49) | LMNAL3MBTL1ALDH1A1POLB | |
| SCHEMBL1327139 | 0.76 | AKR1C3 (0.39) | L3MBTL1AKR1C3POLB | |
| SCHEMBL1327978 | 0.74 | PRMT5 (0.43) | POLB | |
| SCHEMBL2140956 | 0.73 | ALDH1A1 (0.43) | LMNAHRH3CD274KDM4EALDH1A1 | |
| SCHEMBL4824976 | 0.72 | AKR1C3 (0.41) | LMNAL3MBTL1ALDH1A1AKR1C3 | |
| SCHEMBL1327910 | 0.71 | SCN9A (0.43) | LMNAKCNH2MAPK1CASP1CASP7 | |
| SCHEMBL1327671 | 0.70 | C5AR1 (0.46) | LMNAKDM4EALDH1A1 | |
| SCHEMBL1329649 | 0.70 | PTGS1 (0.40) | LMNAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |