Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13496391 | 0.82 | NPC1 (0.46) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL15156887 | 0.82 | NPC1 (0.48) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL2875291 | 0.79 | ALDH1A1 (0.52) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL29739413 | 0.79 | ALDH1A1 (0.52) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL9353505 | 0.78 | MAPT (0.46) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL19965714 | 0.78 | MAPK1 (0.43) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL10355888 | 0.78 | ALDH1A1 (0.48) | MAPTALDH1A1SMN1; SMN2ESR1AR | |
| SCHEMBL3278920 | 0.77 | ESR1 (0.50) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL13882014 | 0.77 | ESR1 (0.46) | NPC1RAB9AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL4827420 | 0.77 | MAPT (0.44) | NPC1RAB9AMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439382-B2 | 4-alkyl-2-haloaniline derivatives and process for producing the same | MEIJI SEIKA KAISHA, LTD. (JP) | 2008-10-21 | — | — | US | disclosed |
| CN-100376542-C | 4-alkyl-2-haloaniline derivative and process for producing the same | MEIJI SEIKA KAISHA (JP) | 2008-03-26 | — | — | CN | disclosed |
| CN-1307160-C | Process for producing 2,3, 6-trialkyl-8-fluoro-4-quinoline derivative | MEIJI SEIKA KAISHA (JP) | 2007-03-28 | — | — | CN | disclosed |
| CN-1668597-A | Process for producing 2,3,6-trialkyl-8-fluoro-4-quinoline derivative | MEIJI SEIKA KAISHA (JP) | 2005-09-14 | — | — | CN | disclosed |
| CN-1653034-A | 4-alkyl-2-haloaniline derivative and process for producing the same | MEIJI SEIKA KAISHA (JP) | 2005-08-10 | — | — | CN | disclosed |
| US-20050143454-A1 | 4-Alkyl-2-haloaniline derivative and process and process for producing the same | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2005-06-30 | — | — | US | disclosed |
| EP-1506954-A1 | 4-ALKYL-2-HALOANILINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | MEIJI SEIKA KAISHA LTD. (JP) | 2005-02-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143454-A1 | 4-Alkyl-2-haloaniline derivative and process and process for producing the same | NAT1, CYP4X1, HAX1 | NPC1 2718/4885RAB9A 811/4885MAPT 4260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.