Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31163885 | 0.82 | RAB9A (0.69) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL4762848 | 0.76 | RAB9A (0.53) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL4763207 | 0.76 | RAB9A (0.50) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL25716799 | 0.75 | RAB9A (0.52) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL6002750 | 0.74 | RAB9A (0.54) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL4760500 | 0.74 | TGFBR1 (0.54) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL4762496 | 0.73 | RAB9A (0.47) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL4762149 | 0.72 | RAB9A (0.51) | RAB9AGAAMMP13MMP1MAPT | |
| SCHEMBL13144514 | 0.72 | MAPT (0.70) | RAB9AGAAMAPTNPC1NPSR1 | |
| SCHEMBL12582252 | 0.72 | RAB9A (0.72) | RAB9AGAAMMP13MMP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |