Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 5/20 | 0.36 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184803 | 0.82 | L3MBTL1 (0.46) | CFTRKDM4EGAAALDH1A1GLA | |
| SCHEMBL22207732 | 0.82 | L3MBTL1 (0.46) | CFTRKDM4EGAAALDH1A1GLA | |
| SCHEMBL1336311 | 0.79 | KDM4E (0.44) | NOS3NOS2KDM4EALDH1A1 | |
| SCHEMBL30781521 | 0.79 | KDM4E (0.44) | NOS3NOS2KDM4EALDH1A1 | |
| SCHEMBL31408890 | 0.79 | MAP2K3 (0.42) | PRKCIATRNOS3NOS2ALDH1A1 | |
| SCHEMBL3548766 | 0.79 | MAPT (0.38) | YTHDC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4828179 | 0.79 | NOS3 (0.47) | PTPN11CFTRPRKCIYTHDC1ATR | |
| SCHEMBL1228642 | 0.76 | GRM4 (0.54) | PTPN11PLK1KDM4EP2RX7GRM5 | |
| SCHEMBL26672365 | 0.76 | PLK1 (0.41) | PLK1KDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL5556257 | 0.75 | GRM6 (0.40) | PRKCIATRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928843-A1 | BIS-ARYL UREA COMPOUNDS FOR THE TREATMENT OF PROTEIN KINASE-MEDIATED DISEAES | Amgen, Inc (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007024754-A1 | BIS-ARYL UREA COMPOUNDS FOR THE TREATMENT OF PROTEIN KINASE-MEDIATED DISEAES | AMGEN INC. (US) | 2007-03-01 | — | — | WO | claimed |