Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | ROS1 | P08922 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4453332 | 0.87 | JAK2 (0.73) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4762218 | 0.85 | JAK2 (0.70) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4378640 | 0.84 | JAK2 (0.51) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4828753 | 0.83 | JAK2 (0.55) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4603072 | 0.82 | JAK2 (0.54) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4584094 | 0.79 | JAK2 (0.59) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4602091 | 0.76 | GSK3B (0.57) | JAK2JAK3HDAC1HDAC6GSK3B | |
| SCHEMBL4381182 | 0.76 | JAK2 (0.60) | JAK2JAK3HDAC1HDAC6CDK2 | |
| SCHEMBL4583408 | 0.75 | JAK2 (0.57) | JAK2JAK3HDAC1HDAC6FLT3 | |
| SCHEMBL34463169 | 0.75 | JAK2 (0.65) | JAK2JAK3HDAC1HDAC6CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |