Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 8/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.47 |
| ▸ | PIM1 | P11309 | 7/20 | 0.47 |
| ▸ | PRKACA | P17612 | 7/20 | 0.47 |
| ▸ | GSK3B | P49841 | 7/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 6/20 | 0.47 |
| ▸ | CDK9 | P50750 | 6/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.47 |
| ▸ | CLK2 | P49760 | 5/20 | 0.47 |
| ▸ | CDK7 | P50613 | 5/20 | 0.47 |
| ▸ | PRKX | P51817 | 5/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 4/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.47 |
| ▸ | CDK8 | P49336 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831120 | 0.88 | RPS6KA5 (0.50) | RPS6KA5CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4832756 | 0.86 | NTRK1 (0.53) | CDK9DYRK1ACDK8CDK2PDPK1 | |
| SCHEMBL8290894 | 0.86 | RPS6KA5 (0.45) | RPS6KA5CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL8290891 | 0.86 | IKBKE (0.35) | RPS6KA5CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL14002240 | 0.85 | PTPN11 (0.41) | RPS6KA5CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4831176 | 0.85 | DYRK1A (0.39) | CDC7DYRK1ACDK8DYRK1BJAK2 | |
| SCHEMBL4829524 | 0.83 | NTRK1 (0.42) | MAP4K4GSK3BCDK5CLK4CLK2 | |
| SCHEMBL4829590 | 0.81 | CDC7 (0.51) | RPS6KA5CDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4827398 | 0.78 | CDC7 (0.53) | CDC7MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL8290070 | 0.78 | DYRK1B (0.44) | RPS6KA5CDC7MAP4K4PIM1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-23 | — | — | US | disclosed |
| WO-2005028475-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, PACSIN2, MAP3K6 | RPS6KA5 130/4885CDC7 276/4885MAP4K4 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.