Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 2/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | CDC7 | O00311 | 5/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.33 |
| ▸ | PIM1 | P11309 | 4/20 | 0.33 |
| ▸ | PRKACA | P17612 | 4/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.33 |
| ▸ | CLK2 | P49760 | 3/20 | 0.33 |
| ▸ | CDK7 | P50613 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | PRKX | P51817 | 3/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4829343 | 0.86 | RPS6KA5 (0.49) | IKBKETBK1RPS6KA5TGFBR1CDC7 | |
| SCHEMBL8290897 | 0.81 | BCAT1 (0.41) | IKBKETBK1TGFBR1CDC7DYRK1A | |
| SCHEMBL8290894 | 0.79 | RPS6KA5 (0.45) | IKBKETBK1RPS6KA5PTPN11TGFBR1 | |
| SCHEMBL14002240 | 0.79 | PTPN11 (0.41) | IKBKETBK1RPS6KA5PTPN11CDC7 | |
| SCHEMBL4831176 | 0.78 | DYRK1A (0.39) | PTPN11CDC7DYRK1ADYRK1BCDK8 | |
| SCHEMBL4829524 | 0.76 | NTRK1 (0.42) | DYRK1AMAP4K4GSK3BCLK4CLK2 | |
| SCHEMBL4832756 | 0.76 | NTRK1 (0.53) | DYRK1ACDK9CDK8PDPK1CDK2 | |
| SCHEMBL8290076 | 0.74 | DYRK1A (0.36) | IKBKETBK1NOTUMPTPN11DYRK1A | |
| SCHEMBL4831120 | 0.74 | RPS6KA5 (0.50) | IKBKETBK1RPS6KA5TGFBR1CDC7 | |
| SCHEMBL8290062 | 0.73 | PTPN11 (0.40) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2005028475-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |