Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.53 |
| ▸ | PRKACA | P17612 | 4/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.52 |
| ▸ | CDK8 | P49336 | 3/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.49 |
| ▸ | CLK2 | P49760 | 4/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831547 | 0.90 | DYRK1A (0.56) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL4829217 | 0.85 | PRKCI (0.50) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL3740263 | 0.83 | CAMKK2 (0.69) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL858985 | 0.81 | CAMKK2 (0.70) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL20846288 | 0.79 | CAMKK2 (0.60) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL4829596 | 0.78 | CDC7 (0.48) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL4829343 | 0.78 | RPS6KA5 (0.49) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL4829590 | 0.78 | CDC7 (0.51) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL4827311 | 0.78 | CDC7 (0.48) | CDC7MAP4K4CLK4HIPK2PRKACA | |
| SCHEMBL4829200 | 0.77 | CDC7 (0.50) | CDC7MAP4K4CLK4HIPK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, PACSIN2, MAP3K6 | CDC7 276/4885MAP4K4 45/4885CLK4 557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.