Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.46 |
| ▸ | CCNC | P24863 | 4/20 | 0.41 |
| ▸ | CDK8 | P49336 | 4/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4829388 | 1.00 | LMNA (0.47) | LMNAKDM4ETP53HSD17B10GRM2 | |
| SCHEMBL4833654 | 0.87 | BRD4 (0.42) | KDM4ECCNCCDK8CDK19RAB9A | |
| SCHEMBL4833668 | 0.87 | BRD4 (0.42) | KDM4ECCNCCDK8CDK19RAB9A | |
| SCHEMBL4829229 | 0.86 | CCNC (0.45) | LMNAKDM4ECCNCCDK8CDK19 | |
| SCHEMBL4829220 | 0.86 | CCNC (0.45) | LMNAKDM4ECCNCCDK8CDK19 | |
| SCHEMBL966357 | 0.85 | CCNC (0.46) | LMNAGRM2CCNCCDK8CDK19 | |
| SCHEMBL966355 | 0.85 | CCNC (0.46) | LMNAGRM2CCNCCDK8CDK19 | |
| SCHEMBL4834441 | 0.84 | GRM2 (0.46) | LMNAKDM4EGRM2CCNCCDK8 | |
| SCHEMBL4834431 | 0.84 | GRM2 (0.46) | LMNAKDM4EGRM2CCNCCDK8 | |
| SCHEMBL4826330 | 0.83 | CCNC (0.49) | CCNCCDK8CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287438-A1 | Agent for preventing or treating neuropathy | MOMOSE YU | 2008-11-20 | — | — | US | disclosed |
| US-7423159-B2 | Agent for preventing or treating neuropathy | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-09 | — | — | US | disclosed |
| US-20060004069-A1 | Agent for preventing or treating neuropathy | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004069-A1 | Agent for preventing or treating neuropathy | NR2C2, NR0B2, NR2E1 | LMNA 2405/4885KDM4E 4406/4885TP53 4623/4885 |
| US-20080287438-A1 | Agent for preventing or treating neuropathy | NR2C2, NR0B2, NR2E1 | LMNA 2405/4885KDM4E 4406/4885TP53 4623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.