Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19523347 | 0.82 | SMN1; SMN2 (0.53) | TSHRHTTSMN1; SMN2 | |
| SCHEMBL7846469 | 0.80 | KCNQ3 (0.41) | NPFFR2GLAGAAMAPTHTT | |
| SCHEMBL3374366 | 0.80 | HTT (0.48) | MAPTHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20241866 | 0.80 | HTT (0.41) | TSHRNPFFR2PHGDHGLAGAA | |
| SCHEMBL10877648 | 0.79 | TSHR (0.55) | TSHRNPFFR2MAPTHDAC3HDAC4 | |
| SCHEMBL9585784 | 0.78 | TSHR (0.60) | TSHRPHGDHSRD5A2 | |
| SCHEMBL1838631 | 0.77 | TSHR (0.44) | TSHRNPFFR2PHGDHGLAGAA | |
| SCHEMBL1838629 | 0.77 | TSHR (0.44) | TSHRNPFFR2PHGDHGLAGAA | |
| SCHEMBL10436207 | 0.76 | LMNA (0.54) | TSHRNPFFR2BCAT2NPFFR1SRD5A2 | |
| SCHEMBL28866121 | 0.76 | BCAT2 (0.65) | TSHRNPFFR2MAPTBCAT2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132174-A1 | DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF | ACURX PHARMACEUTICALS, LLC (US) | 2020-06-25 | — | — | WO | disclosed |
| CN-105753858-A | Heterocyclic compound and p27Kip1 degradation inhibitor | ASKA制药株式会社 | 2016-07-13 | — | — | CN | disclosed |
| CN-102985405-B | Heterocyclic compounds and p27Kip1Decomposition inhibitor | ASKA制药株式会社 | 2016-07-06 | — | — | CN | disclosed |
| US-7439259-B2 | Thiazole derivatives for treating PPAR related disorders | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-21 | — | — | US | disclosed |
| US-20060276519-A1 | THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS | CADILLA RODOLFO | 2006-12-07 | — | — | US | disclosed |
| EP-1343773-B1 | THIAZOLE DERIVATIVES FOR TRAEING PPAR RELATED DISORDERS | SMITHKLINE BEECHAM CORP (US) | 2006-11-02 | — | — | EP | disclosed |
| US-7105551-B2 | Thiazole derivatives for treating PPAR related disorders | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-12 | — | — | US | disclosed |
| US-20040063964-A1 | Thiazole derivatives for treating ppar related disorders | SMITHKLINE BEECHAM CORPORATION | 2004-04-01 | — | — | US | disclosed |
| US-4431652-A | UROGENITAL DISORDERS; KIDNEY AND BLADDER STONES; PROPHYLAXIS; OXIDASE ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1984-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276519-A1 | THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS | PPARG, PPARD, PPARA | TSHR 251/4885NPFFR2 1354/4885PHGDH 871/4885 |
| US-20040063964-A1 | Thiazole derivatives for treating ppar related disorders | PPARG, PPARD, PPARA | TSHR 232/4885NPFFR2 1288/4885PHGDH 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.