Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4235119 | 0.86 | CACNA1B (0.50) | HRH3CACNA1BPOLBMAPTALDH1A1 | |
| SCHEMBL4233071 | 0.85 | ALDH1A1 (0.57) | HRH3CACNA1BPOLBMAPTALDH1A1 | |
| SCHEMBL4832025 | 0.83 | HRH3 (0.60) | HRH3CACNA1BPOLBMAPTALDH1A1 | |
| SCHEMBL4225316 | 0.83 | CACNA1B (0.74) | HRH3CACNA1BPOLBMAPTALDH1A1 | |
| SCHEMBL4234291 | 0.81 | HRH3 (0.62) | HRH3MAPTALDH1A1DRD2PDE4B | |
| SCHEMBL4228386 | 0.80 | KDM4E (0.62) | HRH3CACNA1BPOLBMAPTALDH1A1 | |
| SCHEMBL4234949 | 0.78 | CACNA1B (0.56) | HRH3CACNA1BALDH1A1KDM4EMAOB | |
| SCHEMBL4239664 | 0.78 | CACNA1B (0.56) | HRH3CACNA1BALDH1A1KDM4EMAOB | |
| SCHEMBL4229899 | 0.77 | CACNA1B (0.76) | HRH3CACNA1BPOLBMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL4229804 | 0.77 | CACNA1B (0.55) | HRH3CACNA1BALDH1A1KDM4EMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446103-B2 | Bicyclic benzamide compound as histamine H3 receptor ligand useful in the treatment of neurological diseases | GLAXO GROUP LIMITED (GB) | 2008-11-04 | — | — | US | claimed |