Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.60 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225316 | 0.84 | CACNA1B (0.74) | HRH3CACNA1BALDH1A1POLBMAPT | |
| SCHEMBL4831689 | 0.83 | HRH3 (0.56) | HRH3CACNA1BALDH1A1POLBMAPT | |
| SCHEMBL4233071 | 0.82 | ALDH1A1 (0.57) | HRH3CACNA1BHRH1ALDH1A1POLB | |
| SCHEMBL4224193 | 0.82 | HRH3 (0.61) | HRH3CACNA1BHRH1CYP2D6HRH2 | |
| Hydrochloric Acid SCHEMBL4233278 | 0.82 | HRH3 (0.61) | HRH3CACNA1BHRH1CYP2D6HRH2 | |
| SCHEMBL4233372 | 0.81 | HRH3 (0.64) | HRH3HRH1CYP2D6HRH2KCNH2 | |
| SCHEMBL4229736 | 0.81 | HRH3 (0.63) | HRH3HRH1CYP2D6HRH2KCNH2 | |
| SCHEMBL4229884 | 0.81 | HRH3 (0.63) | HRH3HRH1CYP2D6HRH2KCNH2 | |
| Hydrochloric Acid SCHEMBL4236165 | 0.80 | HRH3 (0.65) | HRH3HRH1CYP2D6HRH2KCNH2 | |
| Hydrochloric Acid SCHEMBL4239620 | 0.80 | HRH3 (0.65) | HRH3HRH1CYP2D6HRH2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446103-B2 | Bicyclic benzamide compound as histamine H3 receptor ligand useful in the treatment of neurological diseases | GLAXO GROUP LIMITED (GB) | 2008-11-04 | — | — | US | claimed |