Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831735 | 0.86 | PTGS1 (0.48) | MAPTALDH1A1LMNAPTGS1PTGS2 | |
| SCHEMBL4831601 | 0.85 | MAPT (0.56) | MAPTALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL4829844 | 0.80 | KDM4E (0.55) | MAPTALDH1A1LMNAPTGS1PTGS2 | |
| SCHEMBL4829754 | 0.76 | PTGS1 (0.44) | MAPTALDH1A1LMNAMAPK1PTGS1 | |
| SCHEMBL10890060 | 0.74 | KCNMA1 (0.77) | MAPTALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL6504452 | 0.74 | CA12 (0.45) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4829643 | 0.74 | PTGS2 (0.52) | MAPTALDH1A1MAPK1PTGS1PTGS2 | |
| SCHEMBL4831957 | 0.74 | MAPT (0.54) | MAPTALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL4829624 | 0.73 | ESR1 (0.44) | MAPTALDH1A1LMNAMAPK1PTGS1 | |
| SCHEMBL6941303 | 0.72 | MAPT (0.60) | MAPTALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |