Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833695 | 0.89 | KCNH2 (0.57) | KCNH2SCN3APRMT5FFAR2ALDH1A1 | |
| SCHEMBL310303 | 0.83 | KCNH2 (0.82) | KCNH2SCN3AFFAR2PARP15PARP10 | |
| SCHEMBL310295 | 0.83 | KCNH2 (0.82) | KCNH2SCN3AFFAR2PARP15PARP10 | |
| SCHEMBL2833224 | 0.79 | KCNH2 (0.57) | KCNH2SCN3APRMT5ALDH1A1ALOX15 | |
| SCHEMBL1104551 | 0.78 | KCNH2 (0.51) | KCNH2SCN3APRMT5FFAR2TRPC6 | |
| SCHEMBL2836952 | 0.78 | KCNH2 (0.83) | KCNH2SCN3APRMT5ALDH1A1ALOX15 | |
| SCHEMBL2837757 | 0.78 | KCNH2 (0.55) | KCNH2SCN3APRMT5ALDH1A1ALOX15 | |
| SCHEMBL483699 | 0.78 | KCNH2 (0.72) | KCNH2SCN3AFFAR2PARP15PARP10 | |
| SCHEMBL1093299 | 0.78 | KCNH2 (0.72) | KCNH2SCN3AFFAR2PARP15PARP10 | |
| SCHEMBL2839989 | 0.77 | KCNH2 (0.54) | KCNH2SCN3APRMT5ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |