Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIFC1 | Q9BW19 | 11/20 | 0.62 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4831832 | 1.00 | KIFC1 (0.62) | KIFC1GPR34PDK1PDK2PDK3 | |
| SCHEMBL5926765 | 0.99 | KIFC1 (0.60) | KIFC1GPR34PDK1PDK2PDK3 | |
| SCHEMBL5926789 | 0.94 | KIFC1 (0.52) | KIFC1GPR34PDK1PDK2PDK3 | |
| SCHEMBL5926814 | 0.88 | PDK1 (0.53) | KIFC1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5927229 | 0.88 | HDAC1 (0.51) | KIFC1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5926379 | 0.87 | KIFC1 (0.51) | KIFC1GPR34PDK1PDK2PDK3 | |
| SCHEMBL5926982 | 0.87 | PDK1 (0.49) | KIFC1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5926135 | 0.86 | PDK1 (0.52) | KIFC1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5926733 | 0.86 | PDK1 (0.56) | KIFC1PDK1PDK2PDK3PDK4 | |
| SCHEMBL5926860 | 0.86 | NR1H4 (0.53) | KIFC1GPR34PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |