SCHEMBL483341

SCHEMBL483341

COC(=O)C1(C(N)=O)CCC(CN)CC1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PLG P00747 1/20 0.36
PLAT P00750 1/20 0.36
LMNA P02545 1/20 0.36
CYP2D6 P10635 1/20 0.34
KCNH2 Q12809 1/20 0.33
TPSAB1 Q15661 1/20 0.31
TPSD1 Q9BZJ3 1/20 0.31
TPSG1 Q9NRR2 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
NCF1 P14598 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1342011 0.79 NPSR1 (0.40) LMNANPSR1MAPT
SCHEMBL15534962 0.79 PLG (0.38) PLGPLATLMNACYP2D6KCNH2
SCHEMBL8928112 0.78 PLG (0.45) PLGPLATLMNACYP2D6KCNH2
SCHEMBL27344356 0.76 PLG (0.36) PLGPLATLMNACYP2D6KCNH2
SCHEMBL1340687 0.75 NPSR1 (0.42) LMNANPSR1MAPT
SCHEMBL1341779 0.75 NPSR1 (0.47) LMNANPSR1MAPT
SCHEMBL4870627 0.74 NPSR1 (0.34) LMNANPSR1MAPT
SCHEMBL595761 0.74 NPSR1 (0.45) LMNANPSR1MAPT
Hydrochloric Acid SCHEMBL27820705 0.72 NPSR1 (0.44) LMNANPSR1MAPT
SCHEMBL2369721 0.71 NPSR1 (0.34) LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1839647-B1 OILY SKIN COMPOSITION FOR EXTERNAL USE FOR ACCELERATING PERCUTANEOUS ABSORPTION SHISEIDO CO LTD (JP) 2012-02-01 EP disclosed
US-20100189754-A1 Oil Based Composition For External Use On Skin For Enhancing Percutaneous Absorption SHISEIDO COMPANY, LTD. (JP) 2010-07-29 US disclosed
US-20080124367-A1 Oil Based Composition For External Use On Skin For Enhancing Percutaneous Absorption SHISEIDO COMPANY, LTD. (JP) 2008-05-29 US disclosed
EP-1839647-A1 OILY SKIN COMPOSITION FOR EXTERNAL USE FOR ACCELERATING PERCUTANEOUS ABSORPTION SHISEIDO COMPANY, LTD. (JP) 2007-10-03 EP disclosed