SCHEMBL483364

SCHEMBL483364

CCCCc1nc2c(N)nc3cccnc3c2n1CCNC(=O)C(N)CC(C)C

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 19/20 0.49
TLR8 Q9NR97 9/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3357603 0.89 TLR7 (0.46) TLR7TLR8
SCHEMBL3350927 0.86 TLR7 (0.52) TLR7TLR8
SCHEMBL8142637 0.86 TLR7 (0.54) TLR7TLR8
SCHEMBL13431445 0.85 TLR7 (0.51) TLR7TLR8
SCHEMBL3350498 0.85 TLR7 (0.48) TLR7TLR8
SCHEMBL3355143 0.83 TLR7 (0.54) TLR7TLR8
SCHEMBL14301420 0.83 TLR7 (0.46) TLR7TLR8
SCHEMBL26351757 0.82 TLR7 (0.53) TLR7TLR8
SCHEMBL18587108 0.82 TLR7 (0.51) TLR7TLR8
SCHEMBL3354252 0.82 TLR7 (0.49) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 159 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230390410-A1 COMPOUNDS AND COMPOSITIONS FOR IMMUNOTHERAPY BIRDIE BIOPHARMACEUTICALS INC (KY) 2023-12-07 US claimed
CN-115554406-A anti-CD 20 combinations for the treatment of tumors 博笛生物科技有限公司 2023-01-03 CN claimed
CN-115350279-A anti-HER 2 combinations for the treatment of tumors 博笛生物科技有限公司 2022-11-18 CN claimed
CN-115337402-A Combination therapeutic compositions and combination therapeutic methods for treating cancer 博笛生物科技有限公司 2022-11-15 CN claimed
CN-115252792-A anti-EGFR combinations for the treatment of tumors 博笛生物科技有限公司 2022-11-01 CN claimed
CN-114716555-A Compounds and compositions for targeting EGFR expressing tumors 博笛生物科技有限公司 2022-07-08 CN claimed
CN-114671954-A Compounds and compositions targeting HER2 positive tumors 博笛生物科技有限公司 2022-06-28 CN claimed
US-20220033503-A1 Anti PD-L1 Conjugates for Treating Tumors BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2022-02-03 US claimed
US-20220016152-A1 IMMUNE MODULATORY COMBINATIONS AND METHODS FOR TREATING CANCERS BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2022-01-20 US claimed
CN-113633783-A Compounds and compositions for immunotherapy 博笛生物科技有限公司 2021-11-12 CN claimed
US-20180110874-A1 Compounds and Compositions for Immunotherapy SHANGHAI BIRDIE BIOTECH, INC. (CN) 2018-04-26 US claimed
EP-3298131-A1 METHOD FOR GENERATING HUMAN DENDRITIC CELLS FOR IMMUNOTHERAPY The Regents of The University of California (US) 2018-03-28 EP claimed
US-9827329-B2 Compounds and compositions for immunotherapy BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2017-11-28 US claimed
US-20170290923-A1 Anti PD-L1 Conjugates for Treating Tumors BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2017-10-12 US claimed
US-20170114137-A1 ANTI-PD-L1 COMBINATIONS FOR TREATING TUMORS SHANGHAI BIRDIE BIOTECH, INC. (CN) 2017-04-27 US claimed
US-20170056391-A1 COMBINATION THERAPY COMPOSITIONS AND METHODS FOR TREATING CANCERS BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2017-03-02 US claimed
US-20170028079-A1 Compounds and Compositions for Treating HER2 Positive Tumors SHANGHAI BIRDIE BIOTECH, INC. (CN) 2017-02-02 US claimed
US-20160375148-A1 Compounds and Compositions for Treating EGFR Expressing Tumors BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2016-12-29 US claimed
WO-2016187459-A1 METHOD FOR GENERATING HUMAN DENDRITIC CELLS FOR IMMUNOTHERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-11-24 WO claimed
US-20160324983-A1 Compounds and Compositions for Immunotherapy SHANGHAI BIRDIE BIOTECH, INC. (CN) 2016-11-10 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170114137-A1 ANTI-PD-L1 COMBINATIONS FOR TREATING TUMORS PDCD1LG2, CD274, PDCD1 TLR7 879/4885TLR8 585/4885
US-20180110874-A1 Compounds and Compositions for Immunotherapy CD47, CD274, TP53 TLR7 147/4885TLR8 313/4885
US-20170056391-A1 COMBINATION THERAPY COMPOSITIONS AND METHODS FOR TREATING CANCERS TP53, MCL1, MSH2 TLR7 1537/4885TLR8 2076/4885
US-20170028079-A1 Compounds and Compositions for Treating HER2 Positive Tumors ERBB2, EGFR, TP53 TLR7 362/4885TLR8 249/4885
US-20220033503-A1 Anti PD-L1 Conjugates for Treating Tumors CD274, PDCD1LG2, PDCD1 TLR7 883/4885TLR8 671/4885
US-20220016152-A1 IMMUNE MODULATORY COMBINATIONS AND METHODS FOR TREATING CANCERS CD47, IFNG, GZMB TLR7 97/4885TLR8 84/4885
US-20160324983-A1 Compounds and Compositions for Immunotherapy CD47, TP53, CD74 TLR7 198/4885TLR8 159/4885
US-20160375148-A1 Compounds and Compositions for Treating EGFR Expressing Tumors EGFR, ERBB2, ERBB3 TLR7 634/4885TLR8 518/4885
US-20170290923-A1 Anti PD-L1 Conjugates for Treating Tumors CD274, PDCD1LG2, PDCD1 TLR7 980/4885TLR8 901/4885
US-20230390410-A1 COMPOUNDS AND COMPOSITIONS FOR IMMUNOTHERAPY CD47, CD274, TP53 TLR7 147/4885TLR8 313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.