Sugi Predict

Sugi Predict / Compounds / SCHEMBL4834122

SCHEMBL4834122

SCHEMBL4834122

NC1=c2ccoc2=NCN1c1ccc(NS(=O)(=O)c2c(Cl)cc(C(F)(F)F)cc2Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PFKFB4 Q16877 1/20 0.38
▸ SGK1 O00141 1/20 0.34
▸ MAPT P10636 3/20 0.33
▸ MCL1 Q07820 2/20 0.33
▸ NPY5R Q15761 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ XBP1 P17861 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ SCN9A Q15858 2/20 0.33
▸ CYP2D6 P10635 4/20 0.32
▸ PSEN1 P49768 4/20 0.32
▸ PSEN2 P49810 4/20 0.32
▸ APH1B Q8WW43 4/20 0.32
▸ NCSTN Q92542 4/20 0.32
▸ APH1A Q96BI3 4/20 0.32
▸ PSENEN Q9NZ42 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4833691 0.88 PSEN1 (0.44) MAPTNPY5RLMNACYP2D6PSEN1
SCHEMBL4826056 0.86 ATM (0.40) SGK1MAPTMCL1MEN1LMNA
SCHEMBL4831000 0.85 NPY5R (0.45) MAPTNPY5RMEN1LMNAKMT2A
SCHEMBL4834223 0.82 CA1 (0.42) MAPTMEN1KMT2ACA1CA2
SCHEMBL4833952 0.81 TRAP1 (0.35) SGK1NPY5RLMNASCN9ACA1
SCHEMBL4829022 0.81 MAPT (0.49) MAPTMEN1LMNAHTTKMT2A
SCHEMBL4834472 0.81 CYP3A4 (0.47) CYP2D6PSEN1PSEN2APH1BNCSTN
SCHEMBL4836618 0.80 MEN1 (0.42) MAPTMEN1LMNAHTTKMT2A
SCHEMBL4828759 0.80 SGK1 (0.43) SGK1MAPTMEN1LMNAKMT2A
SCHEMBL4831388 0.80 ALDH1A1 (0.56) SGK1MAPTMEN1LMNAXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080287466-A1 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF ADAMS JERRY LEROY 2008-11-20 — — US claimed
US-20050004142-A1 Chemical compounds SMITHKLINE BEECHAM CORPORATION 2005-01-06 — — US claimed
US-20080287466-A1 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF ADAMS JERRY LEROY 2008-11-20 — — US disclosed
US-7427623-B2 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof SMITHKLINE BEECHAM CORPORATION (US) 2008-09-23 — — US disclosed
US-20050004142-A1 Chemical compounds SMITHKLINE BEECHAM CORPORATION 2005-01-06 — — US disclosed
EP-1425284-A2 FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2004-06-09 — — EP disclosed
WO-2003022852-A2 FURO-AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-03-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050004142-A1 Chemical compounds TIE1, KDR, TEK PFKFB4 804/4885SGK1 2615/4885MAPT 2499/4885
US-20080287466-A1 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF TIE1, TEK, KDR PFKFB4 794/4885SGK1 4345/4885MAPT 2424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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