Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483601 | 1.00 | KCNH2 (0.51) | KCNH2MAOBNR4A2FFAR2SPHK1 | |
| SCHEMBL311548 | 0.87 | KCNH2 (0.59) | KCNH2MAOBNR4A2FFAR2LMNA | |
| SCHEMBL310922 | 0.87 | KCNH2 (0.59) | KCNH2MAOBNR4A2FFAR2LMNA | |
| SCHEMBL310672 | 0.87 | KCNH2 (0.59) | KCNH2MAOBNR4A2FFAR2LMNA | |
| SCHEMBL483621 | 0.87 | KCNH2 (0.59) | KCNH2MAOBNR4A2FFAR2LMNA | |
| SCHEMBL2832488 | 0.86 | FFAR2 (0.52) | KCNH2MAOBNR4A2FFAR2SPHK1 | |
| SCHEMBL2840464 | 0.82 | FFAR2 (0.46) | KCNH2MAOBFFAR2SPHK1GRIN1 | |
| SCHEMBL2837028 | 0.80 | KCNH2 (0.57) | KCNH2MAOBNR4A2FFAR2SPHK1 | |
| SCHEMBL20886555 | 0.77 | KCNH2 (0.56) | KCNH2MAOBFFAR2LMNAKDM4E | |
| SCHEMBL24310075 | 0.77 | CHRNB2 (0.59) | KCNH2MAOBSPHK1KDM2BSPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |