Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | EZH2 | Q15910 | 8/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483784 | 0.86 | KCNH2 (0.51) | KCNH2ALDH1A1 | |
| SCHEMBL2837158 | 0.79 | KCNH2 (0.53) | KCNH2EZH2MAPK14POLBGAA | |
| SCHEMBL311657 | 0.79 | KCNH2 (0.46) | KCNH2NPC1RAB9ATP53 | |
| SCHEMBL483795 | 0.75 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL310676 | 0.75 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL483566 | 0.74 | KCNH2 (0.49) | KCNH2EZH2MAPK14POLBGAA | |
| SCHEMBL2835462 | 0.71 | KCNH2 (0.57) | KCNH2EZH2MAPK14POLBGAA | |
| SCHEMBL483073 | 0.70 | KCNH2 (0.61) | KCNH2EZH2MAPK14POLBGAA | |
| SCHEMBL12973281 | 0.69 | KCNH2 (0.52) | KCNH2EZH2MAPK14POLBGAA | |
| SCHEMBL2831512 | 0.69 | KCNH2 (0.47) | KCNH2EZH2MAPK14POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |