SCHEMBL4835982

SCHEMBL4835982

CC(C)Oc1ccc(C(=O)NC(Cc2ccc(-c3c[nH]c(CC(C)(C)C)n3)cc2)CN(C)C(N)=O)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CENPE Q02224 3/20 0.46
KIFC1 Q9BW19 1/20 0.42
S1PR1 P21453 5/20 0.35
TAS1R3 Q7RTX0 1/20 0.34
TAS1R1 Q7RTX1 1/20 0.34
ROCK2 O75116 4/20 0.34
ROCK1 Q13464 4/20 0.34
KMO O15229 2/20 0.34
WDR5 P61964 1/20 0.33
S1PR3 Q99500 1/20 0.33
S1PR5 Q9H228 1/20 0.33
HDAC4 P56524 2/20 0.33
HDAC6 Q9UBN7 2/20 0.33
PDK1 Q15118 1/20 0.32
PDK2 Q15119 1/20 0.32
PDK3 Q15120 1/20 0.32
PDK4 Q16654 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13161750 0.82 CENPE (0.51) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL3462357 0.82 CENPE (0.51) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL4835978 0.81 CENPE (0.44) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL4899980 0.76 CENPE (0.47) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL13584838 0.75 CENPE (0.47) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL13584837 0.75 CENPE (0.47) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL5569230 0.75 CENPE (0.37) CENPEKIFC1S1PR1KMOWDR5
SCHEMBL3468364 0.71 CENPE (0.50) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL13626786 0.71 CENPE (0.50) CENPEKIFC1S1PR1TAS1R3TAS1R1
SCHEMBL14031457 0.70 CENPE (0.49) CENPEKIFC1S1PR1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1742907-A4 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS INC (US) 2008-01-02 EP disclosed
EP-1742907-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS Cytokinetics, Inc. (US) 2007-01-17 EP disclosed
WO-2005107762-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2005-11-17 WO disclosed