SCHEMBL483620

SCHEMBL483620

COCCc1nc2c(N)nc3ccccc3c2n1CCOCCN(C)S(C)(=O)=O

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 19/20 0.54
TLR8 Q9NR97 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30854928 1.00 TLR7 (0.54) TLR7TLR8
SCHEMBL5119677 0.91 TLR8 (0.51) TLR7TLR8
SCHEMBL1890833 0.89 TLR8 (0.59) TLR7TLR8
SCHEMBL31006041 0.87 TLR8 (0.55) TLR7TLR8
SCHEMBL5113123 0.85 TLR7 (0.62) TLR7TLR8
SCHEMBL6031026 0.84 TLR7 (0.57) TLR7TLR8
SCHEMBL1043163 0.84 TLR8 (0.74) TLR7TLR8
SCHEMBL5736958 0.83 TLR7 (0.56) TLR7TLR8
SCHEMBL4331154 0.82 TLR7 (0.56) TLR7TLR8
SCHEMBL4336407 0.82 TLR7 (0.55) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1341790-B1 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES CO (US) 2007-02-14 EP claimed
US-7132429-B2 Sulfonamido ether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-11-07 US claimed
US-20050148619-A1 Sulfonamido ether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2005-07-07 US claimed
US-20040097542-A1 Sulfonamido ether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2004-05-20 US claimed
US-20040092545-A1 Sulfonamido ether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2004-05-13 US claimed
US-6683088-B2 CAN INDUCE THE BIOSYNTHESIS OF VARIOUS CYTOKINES AND ARE USEFUL IN THERAPY OF VIRAL DISEASES AND NEOPLASTIC DISEASES 3M INNOVATIVE PROPERTIES COMPANY 2004-01-27 US claimed
EP-1341790-A2 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2003-09-10 EP claimed
US-20030139441-A1 Sulfonamido ether substituted imidazoquinolines UBS AG, STAMFORD BRANCH 2003-07-24 US claimed
US-20020193396-A1 Sulfonamido ether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2002-12-19 US claimed
WO-2002046190-A2 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2002-06-13 WO claimed
US-20250152703-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-05-15 US disclosed
US-12201684-B2 Compositions for stimulation of mammalian innate immune resistance to pathogens THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-01-21 US disclosed
US-11826422-B2 Methods and compositions for adaptive immune modulation BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-11-28 US disclosed
US-20200345842-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-11-05 US disclosed
US-10722573-B2 Compositions for stimulation of mammalian innate immune resistance to pathogens THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-07-28 US disclosed
US-6677347-B2 ANTICARCINOGENIC AND ANTITUMOR AGENTS; VIRICIDED, IMMUNOMODULATORS 3M INNOVATIVE PROPERTIES COMPANY 2004-01-13 US disclosed
EP-1341790-A2 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2003-09-10 EP disclosed
US-20030139441-A1 Sulfonamido ether substituted imidazoquinolines UBS AG, STAMFORD BRANCH 2003-07-24 US disclosed
US-20020193396-A1 Sulfonamido ether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2002-12-19 US disclosed
WO-2002046190-A2 SULFONAMIDO ETHER SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2002-06-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040092545-A1 Sulfonamido ether substituted imidazoquinolines IFNG, IRF3, IL2 TLR7 24/4885TLR8 50/4885
US-20030139441-A1 Sulfonamido ether substituted imidazoquinolines IFNG, IRF3, IL2 TLR7 24/4885TLR8 50/4885
US-20050148619-A1 Sulfonamido ether substituted imidazoquinolines IFNG, IRF3, IL2 TLR7 24/4885TLR8 50/4885
US-20040097542-A1 Sulfonamido ether substituted imidazoquinolines IFNG, IRF3, IL2 TLR7 24/4885TLR8 50/4885
US-20020193396-A1 Sulfonamido ether substituted imidazoquinolines IFNG, IRF3, IL2 TLR7 24/4885TLR8 50/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.