Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4835344 | 0.99 | TACR1 (0.48) | TACR1SMN1; SMN2KMT2AHTTPOLB | |
| SCHEMBL4830947 | 0.89 | ALDH1A1 (0.55) | TACR1SMN1; SMN2KMT2AALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL4836884 | 0.88 | ALDH1A1 (0.54) | TACR1SMN1; SMN2KMT2AALDH1A1MAPK1 | |
| SCHEMBL4838738 | 0.88 | KMT2A (0.49) | SMN1; SMN2KMT2AOPRL1ALDH1A1MAPK1 | |
| SCHEMBL4831023 | 0.88 | LIPE (0.45) | TACR1KMT2AALDH1A1TSHRCCR5 | |
| Hydrochloric Acid SCHEMBL4831009 | 0.87 | KMT2A (0.48) | TACR1SMN1; SMN2KMT2AOPRL1ALDH1A1 | |
| SCHEMBL4836256 | 0.87 | KMT2A (0.48) | TACR1SMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL4831071 | 0.87 | KMT2A (0.48) | TACR1SMN1; SMN2KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL4833360 | 0.87 | LIPE (0.45) | TACR1KMT2AALDH1A1TSHRCCR5 | |
| Hydrochloric Acid SCHEMBL4827786 | 0.86 | KMT2A (0.47) | TACR1SMN1; SMN2KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351713-B2 | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity | VIRO CHEM PHARMA, INC. (CA) | 2008-04-01 | — | — | US | claimed |
| US-20050075360-A1 | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity | VIRO CHEM PHARMA, INC. (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075360-A1 | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | TACR1 39/4885SMN1; SMN2 4745/4885KMT2A 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.