SCHEMBL4837456

SCHEMBL4837456

O=C(OCc1cccc2c1C(COC(=O)c1ccccc1)c1ccccc1-2)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.51
KMT2A Q03164 3/20 0.45
TDP1 Q9NUW8 2/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A3 Q01959 1/20 0.45
EPHX2 P34913 1/20 0.43
FABP5 Q01469 3/20 0.42
FABP7 O15540 2/20 0.42
MAPK1 P28482 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
LMNA P02545 2/20 0.39
HIF1A Q16665 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
NPC1 O15118 1/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16381002 0.84 FABP5 (0.55) KMT2ATDP1SLC6A2SLC6A3EPHX2
SCHEMBL31684010 0.84 FABP5 (0.55) KMT2ATDP1SLC6A2SLC6A3EPHX2
SCHEMBL4839883 0.78 EPHX2 (0.43) KMT2AEPHX2FABP5FABP7LMNA
SCHEMBL4577944 0.76 PPARG (0.65) PPARGKMT2ATDP1SLC6A2SLC6A3
SCHEMBL5085480 0.74 PPARG (0.71) PPARGKMT2ATDP1SLC6A2SLC6A3
SCHEMBL34469817 0.73 FABP5 (0.50) KMT2ATDP1SLC6A2SLC6A3EPHX2
SCHEMBL27514510 0.73 L3MBTL1 (0.51) KMT2AEPHX2FABP5FABP7LMNA
SCHEMBL27519520 0.72 KMT2A (0.58) KMT2AEPHX2FABP5FABP7
SCHEMBL15272782 0.72 HTR2A (0.38) KMT2AEPHX2FABP5FABP7
SCHEMBL29025357 0.70 KMT2A (0.56) KMT2ATDP1MAPK1LMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478730-A1 PROCATALYST COMPOSITIONS USEFUL FOR LOW COMONOMER INCORPORATION AND PROCESS FOR PREPARING THE SAME Dow Global Technologies LLC (US) 2019-05-08 EP disclosed
WO-2018005789-A1 PROCATALYST COMPOSITIONS USEFUL FOR LOW COMONOMER INCORPORATION AND PROCESS FOR PREPARING THE SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2018-01-04 WO disclosed
US-20120252992-A1 CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST COMPRISING THE SAME CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2012-10-04 US disclosed
US-7388061-B2 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-06-17 US disclosed
US-20050239636-A1 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2005-10-27 US disclosed