Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282713 | 0.80 | CA12 (0.50) | CA12CA1CA2CA9TSHR | |
| SCHEMBL11683810 | 0.80 | CA12 (0.50) | CA12CA1CA2CA9TSHR | |
| SCHEMBL10508956 | 0.78 | CA12 (0.48) | CA12CA1CA2CA9TSHR | |
| SCHEMBL2994641 | 0.78 | CA12 (0.48) | CA12CA1CA2CA9TSHR | |
| SCHEMBL6734130 | 0.78 | CA12 (0.48) | CA12CA1CA2CA9TSHR | |
| SCHEMBL11514054 | 0.78 | CA12 (0.48) | CA12CA1CA2CA9TSHR | |
| SCHEMBL2240528 | 0.76 | CA12 (0.47) | CA12CA1CA2CA9TSHR | |
| SCHEMBL2236212 | 0.76 | CA12 (0.52) | CA12CA1CA2CA9TSHR | |
| SCHEMBL9051636 | 0.74 | TSHR (0.48) | CA12CA1CA2CA9TSHR | |
| SCHEMBL2356791 | 0.74 | TSHR (0.48) | CA12CA1CA2CA9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097160-A4 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIV SOUTHERN CALIFORNIA (US) | 2002-06-12 | — | — | EP | claimed |
| EP-1097160-A1 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2001-05-09 | — | — | EP | claimed |
| US-6147245-A | Preparation and use of α-Keto Bisphosphonates | UNIVERSITY OF SOUTHERN CALIFORNIA UNIVERSITY PARK (US) | 2000-11-14 | — | — | US | claimed |
| WO-2000002889-A1 | PREPARATION AND USE OF α-KETO BISPHOSPHONATES | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2000-01-20 | — | — | WO | claimed |
| US-7462733-B2 | Preparation and use of α-keto phosphonates | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2008-12-09 | — | — | US | disclosed |
| US-20040236135-A1 | Preparation and use of alpha-keto phosphonates | SOUTHERN CALIFORNIA, UNIVERSITY OF | 2004-11-25 | — | — | US | disclosed |
| WO-2003011221-A2 | PREPARATION AND USE OF α-KETO PHOSPHONATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2003-02-13 | — | — | WO | disclosed |
| EP-1097160-A4 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIV SOUTHERN CALIFORNIA (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1097160-A1 | PREPARATION AND USE OF ALPHA-KETO BISPHOSPHONATES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6147245-A | Preparation and use of α-Keto Bisphosphonates | UNIVERSITY OF SOUTHERN CALIFORNIA UNIVERSITY PARK (US) | 2000-11-14 | — | — | US | disclosed |
| WO-2000002889-A1 | PREPARATION AND USE OF α-KETO BISPHOSPHONATES | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236135-A1 | Preparation and use of alpha-keto phosphonates | PNKP, PFKFB1, PDXK | CA12 3012/4885CA1 2663/4885CA2 2937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.