⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8056827 | 0.82 | — | — | |
| SCHEMBL7154948 | 0.80 | FDPS (0.48) | — | |
| SCHEMBL4063363 | 0.80 | FDPS (0.48) | — | |
| SCHEMBL48663 | 0.78 | — | — | |
| Bromide SCHEMBL29657458 | 0.78 | FDPS (0.47) | — | |
| Bromide SCHEMBL273017 | 0.76 | — | — | |
| SCHEMBL1208324 | 0.76 | — | — | |
| Water SCHEMBL15333942 | 0.76 | — | — | |
| SCHEMBL14025201 | 0.76 | — | — | |
| SCHEMBL1427464 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63030471-A | — | — | None | — | — | JP | disclosed |
| CN-108026067-B | 6-amino-quinoline-3-carbonitriles as COT modulators | 吉利德科学公司 | 2021-01-12 | — | — | CN | disclosed |
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |
| CN-1926139-A | Fused pyrazole derivatives | HOFFMANN LA ROCHE (CH) | 2007-03-07 | — | — | CN | disclosed |
| EP-1737865-A1 | FUSED DERIVATIVES OF PYRAZOLE | F.HOFFMANN-LA ROCHE AG (CH) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005085249-A1 | FUSED DERIVATIVES OF PYRAZOLE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |
| US-20050197340-A1 | Fused-pyrazolo pyrimidine and pyrazolo pyrimidinone derivatives and methods for using the same | ROCHE PALO ALTO LLC | 2005-09-08 | — | — | US | disclosed |
| US-5945419-A | ATOPIC DERMITITIS, RHINITIS; ADMINISTERING | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-08-31 | — | — | US | disclosed |
| WO-1999037636-A1 | HETEROCYCLYL-DERIVATIVES | NIHON BAYER AGROCHEM K.K. (DE) | 1999-07-29 | — | — | WO | disclosed |
| US-5922712-A | ADMINISTERING TRIAZOLOPYRIDAZINE DERIVATIVE FOR TREATING THE DISEASES INVOLVING EOSINOPHILIA, SUCH AS ALLERIC RHINITIS, AND ATOPIC DERMATITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-13 | — | — | US | disclosed |
| EP-0865790-A2 | Use of triazolopyridazine derivatives in the manufacture of a medicament for the treatment of atopic dermatitis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-23 | — | — | EP | disclosed |
| EP-0648491-A2 | Eosinophil chemotaxis inhibitor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| JP-S6330471-A | NOVEL IMIDAZOLEUREA COMPOUND, SYNTHESIS THEREOF AND CURING METHOD FOR POLYEPOXY RESIN USING SAID COMPOUND | SHIKOKU CHEM CORP | 1988-02-09 | — | — | JP | disclosed |