SCHEMBL4837997

SCHEMBL4837997

CC(C)(C(=O)O)c1ccc(OCCNC(=O)[C@@H]2Cc3ccccc3N2S(=O)(=O)c2ccc(-c3cc(C(F)(F)F)ccc3Cl)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.43
CACNA1B Q00975 1/20 0.38
RORC P51449 4/20 0.38
ALDH1A1 P00352 2/20 0.37
NPSR1 Q6W5P4 2/20 0.37
MMP8 P22894 6/20 0.37
MMP3 P08254 3/20 0.37
TRPA1 O75762 1/20 0.35
PTGER3 P43115 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
POLB P06746 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ALOX5 P09917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4842917 0.94 FFAR4 (0.41) FFAR4CACNA1BRORCALDH1A1NPSR1
SCHEMBL4833426 0.92 FFAR4 (0.40) FFAR4RORCALDH1A1NPSR1MMP8
SCHEMBL4832552 0.92 FFAR4 (0.44) FFAR4CACNA1BRORCALDH1A1NPSR1
SCHEMBL4841606 0.91 FFAR4 (0.43) FFAR4RORCALDH1A1NPSR1MMP8
SCHEMBL4845420 0.91 FFAR4 (0.43) FFAR4RORCALDH1A1NPSR1MMP8
SCHEMBL4842437 0.90 FFAR4 (0.41) FFAR4CACNA1BRORCALDH1A1NPSR1
SCHEMBL4837553 0.89 FFAR4 (0.40) FFAR4RORCALDH1A1NPSR1MMP8
SCHEMBL4843247 0.89 FFAR4 (0.40) FFAR4RORCALDH1A1NPSR1MMP8
SCHEMBL4841148 0.89 FFAR4 (0.41) FFAR4RORCALDH1A1NPSR1MMP8
SCHEMBL4832894 0.89 FFAR4 (0.40) FFAR4RORCALDH1A1NPSR1MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7465811-B2 Indoline compounds LABORATOIRES FOURNIER S.A. (FR) 2008-12-16 US disclosed
US-20080119465-A1 Novel Indoline Compounds LABORATORIES FOURNIER S.A. (FR) 2008-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119465-A1 Novel Indoline Compounds GPR119, INSR, IRS1 FFAR4 125/4885CACNA1B 1324/4885RORC 1777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.