Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR1 | P47211 | 5/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 4/20 | 0.36 |
| ▸ | GALR2 | O43603 | 4/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030764 | 0.99 | GALR1 (0.40) | GALR1BCL6CTSLCTSSCTSK | |
| SCHEMBL5032423 | 0.91 | BCL6 (0.44) | GALR1BCL6CTSLCTSSCTSK | |
| Hydrochloric Acid SCHEMBL4838602 | 0.87 | GALR1 (0.40) | GALR1BCL6CTSLCTSSCTSK | |
| SCHEMBL4836907 | 0.85 | GALR1 (0.40) | GALR1BCL6CTSLCTSSCTSK | |
| SCHEMBL5032241 | 0.85 | BCL6 (0.46) | GALR1BCL6CTSLCTSSCTSK | |
| SCHEMBL4837869 | 0.84 | BCL6 (0.45) | GALR1BCL6CTSLCTSSCTSK | |
| SCHEMBL6233888 | 0.81 | GALR2 (0.38) | GALR1CTSLCTSSCTSKGALR2 | |
| SCHEMBL4836141 | 0.81 | BCL6 (0.48) | GALR1BCL6CTSLCTSSCTSK | |
| SCHEMBL4838644 | 0.80 | IDH2 (0.40) | BCL6AXLCCNT1CDK4CCND1 | |
| SCHEMBL4829497 | 0.80 | BCL6 (0.39) | GALR1BCL6CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332489-B2 | Methods and compositions of novel triazine compounds | REDDY US THERAPEUTICS, INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-7132423-B2 | Methods and compositions of novel triazine compounds | REDDY US THERAPEUTICS, INC. (US) | 2006-11-07 | — | — | US | disclosed |