Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 6/20 | 0.44 |
| ▸ | CA9 | Q16790 | 6/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CA5A | P35218 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phloroglucinol SCHEMBL26311 | 0.85 | — | — | |
| Phloroglucinol SCHEMBL30542958 | 0.85 | — | — | |
| Phloroglucinol SCHEMBL2889628 | 0.85 | BACE1 (1.00) | BACE1LCKACHECA12CA9 | |
| Phloroglucinol SCHEMBL310716 | 0.80 | BACE1 (0.89) | BACE1LCKACHECA12CA9 | |
| Phloroglucinol SCHEMBL10916023 | 0.80 | BACE1 (0.89) | BACE1LCKACHECA12CA9 | |
| Phloroglucinol SCHEMBL23346245 | 0.80 | BACE1 (0.89) | BACE1LCKACHECA12CA9 | |
| Phloroglucinol SCHEMBL5495237 | 0.80 | BACE1 (0.89) | BACE1LCKACHECA12CA9 | |
| Phloroglucinol SCHEMBL1913949 | 0.80 | BACE1 (0.89) | BACE1LCKACHECA12CA9 | |
| Phloroglucinol SCHEMBL502610 | 0.80 | BACE1 (0.89) | BACE1LCKACHECA12CA9 | |
| Phloroglucinol SCHEMBL28463308 | 0.80 | BACE1 (0.89) | BACE1LCKACHECA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399094-B2 | Multilayer laminated articles including polyurethane and/or poly(ureaurethane) layers and methods of making the same | PPG INDUSTRIES OHIO, INC. (US) | 2013-03-19 | — | — | US | claimed |
| US-20250136838-A1 | POLYCARBONATE-BASED POLYURETHANE TOPCOATS | PRC-DESOTO INTERNATIONAL, INC. (US) | 2025-05-01 | — | — | US | disclosed |
| EP-3559069-B9 | POLYURETHANE PREPOLYMERS INCORPORATING NONLINEAR SHORT CHAIN DIOLS AND/OR SOFT DIISOCYANATES COMPOSITIONS, AND USES THEREOF | PRC DESOTO INT INC (US) | 2024-10-23 | — | — | EP | disclosed |
| US-20240309150-A1 | POLYESTER POLYMER | PPG INDUSTRIES OHIO, INC. (US) | 2024-09-19 | — | — | US | disclosed |
| EP-3559069-B1 | POLYURETHANE PREPOLYMERS INCORPORATING NONLINEAR SHORT CHAIN DIOLS AND/OR SOFT DIISOCYANATES COMPOSITIONS, AND USES THEREOF | PRC DESOTO INT INC (US) | 2024-08-14 | — | — | EP | disclosed |
| US-12036769-B2 | Ultraviolet protective transparency | PPG INDUSTRIES OHIO, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-11898054-B2 | Actinic radiation-curable urethane/urea-containing aerospace coatings and sealants | PRC-DESOTO INTERNATIONAL, INC. (US) | 2024-02-13 | — | — | US | disclosed |
| US-11807707-B2 | Polyurethane prepolymers incorporating nonlinear short chain diols and/or soft diisocyanates compositions, and uses thereof | PRC-DESOTO INTERNATIONAL, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| EP-4169709-A1 | ULTRAVIOLET PROTECTIVE TRANSPARENCY | PPG Industries Ohio, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| US-20230120549-A1 | Polyurethanes, Articles and Coatings Prepared Therefrom and Methods of Making the Same | PPG INDUSTRIES OHIO, INC. | 2023-04-20 | — | — | US | disclosed |
| US-20070155936-A1 | Polyurethanes, articles and coatings prepared therefrom and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070155942-A1 | Polyurethanes, articles and coatings prepared therefrom and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070155895-A1 | Poly(ureaurethane)s, articles and coatings prepared therefrom and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070155935-A1 | Poly(ureaurethane)s, articles and coatings prepared therefrom and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-07-05 | — | — | US | disclosed |
| WO-2007073474-A1 | IMPACT RESISTANT POLYURETHANE AND POLY(UREAURETHANE) ARTICLES AND METHODS OF MAKING THE SAME | PPG INDUSTRIES OHIO, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
| US-20070149749-A1 | Polyurethanes prepared from polycarbonate polyols, articles and coatings prepared therefrom and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-06-28 | — | — | US | disclosed |
| US-20070149748-A1 | Poly(ureaurethane)s, articles and coatings prepared therefrom and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-06-28 | — | — | US | disclosed |
| US-20070149747-A1 | Poly(ureaurethane)s, articles and coatings prepared therefrom and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-06-28 | — | — | US | disclosed |
| US-20070148471-A1 | Impact resistant polyurethane and poly(ureaurethane) articles and methods of making the same | PPG INDUSTRIES OHIO, INC. | 2007-06-28 | — | — | US | disclosed |
| WO-2007070627-A2 | POLYURETHANES, ARTICLES AND COATINGS PREPARED THEREFROM AND METHODS OF MAKING THE SAME | PPG INDUSTRIES OHIO, INC. (US) | 2007-06-21 | — | — | WO | disclosed |