Sugi Predict

Sugi Predict / Compounds / Gw275616X

Gw275616X

Gw275616X

SCHEMBL4839162

NS(=O)(=O)c1cccc(NC=C2C(=O)Nc3ccccc32)c1

nearest known ligand 0.52

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 7/20 0.52
▸ CA2 P00918 7/20 0.52
▸ CA9 Q16790 4/20 0.48
▸ NT5E P21589 3/20 0.48
▸ POLB P06746 1/20 0.47
▸ MAPT P10636 4/20 0.45
▸ ALDH1A1 P00352 3/20 0.45
▸ CA12 O43570 3/20 0.45
▸ KDM4E B2RXH2 1/20 0.45
▸ PKM P14618 1/20 0.45
▸ MAPK1 P28482 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.45
▸ PDPK1 O15530 1/20 0.45
▸ CA4 P22748 2/20 0.44
▸ NTRK1 P04629 1/20 0.43
▸ SYK P43405 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ TGM2 P21980 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gw275616X SCHEMBL4839155 1.00 CA1 (0.52) CA1CA2CA9NT5EPOLB
SCHEMBL7899300 0.86 POLB (0.55) CA1CA2CA9NT5EPOLB
SCHEMBL4994672 0.86 POLB (0.55) CA1CA2CA9NT5EPOLB
SCHEMBL4991565 0.82 ALK (0.50) MAPTALDH1A1KDM4EPKMMAPK1
SCHEMBL4991559 0.82 ALK (0.50) MAPTALDH1A1KDM4EPKMMAPK1
SCHEMBL4996412 0.80 PRKCA (0.50) MAPTALDH1A1KDM4EPKMMAPK1
SCHEMBL4996402 0.80 PRKCA (0.50) MAPTALDH1A1KDM4EPKMMAPK1
SCHEMBL3811533 0.80 MAPT (0.58) MAPTALDH1A1KDM4EPKMMAPK1
SCHEMBL3811532 0.80 MAPT (0.58) MAPTALDH1A1KDM4EPKMMAPK1
SCHEMBL14822865 0.80 MAPT (0.58) MAPTALDH1A1KDM4EPKMMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7338966-B2 Substituted oxindole derivatives as tyrosine kinase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 2008-03-04 — — US claimed
US-20050228025-A1 Substituted oxindole derivatives as tyrosine kinase inhibitors DICKERSON SCOTT H 2005-10-13 — — US claimed
US-20030195234-A1 Substituted oxindole derivatives as tyrosine kinase inhibitors SMITHKLINE BEECHAM CORPORATION 2003-10-16 — — US claimed
US-7338966-B2 Substituted oxindole derivatives as tyrosine kinase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 2008-03-04 — — US disclosed
US-7071217-B2 Substituted oxindole derivatives as tyrosine kinase inhibitors SMITHKLINE BEECHAM CORPORATION (US) 2006-07-04 — — US disclosed
US-20050228025-A1 Substituted oxindole derivatives as tyrosine kinase inhibitors DICKERSON SCOTT H 2005-10-13 — — US disclosed
US-20030195234-A1 Substituted oxindole derivatives as tyrosine kinase inhibitors SMITHKLINE BEECHAM CORPORATION 2003-10-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030195234-A1 Substituted oxindole derivatives as tyrosine kinase inhibitors FRK, LTK, ERBB2 CA1 4845/4885CA2 4400/4885CA9 4805/4885
US-20050228025-A1 Substituted oxindole derivatives as tyrosine kinase inhibitors LTK, FRK, ERBB2 CA1 4776/4885CA2 3828/4885CA9 4563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.