Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 5/20 | 0.52 |
| ▸ | CA2 | P00918 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.52 |
| ▸ | CA9 | Q16790 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4994672 | 1.00 | POLB (0.55) | POLBCA1CA2ALDH1A1CA12 | |
| SCHEMBL5426663 | 0.87 | MAPT (0.48) | POLBCA1CA2ALDH1A1MAPT | |
| Gw275616X SCHEMBL4839162 | 0.86 | CA1 (0.52) | POLBCA1CA2ALDH1A1CA12 | |
| Gw275616X SCHEMBL4839155 | 0.86 | CA1 (0.52) | POLBCA1CA2ALDH1A1CA12 | |
| SCHEMBL23306698 | 0.85 | ALDH1A1 (0.47) | POLBALDH1A1MAPTPKMMAPK1 | |
| SCHEMBL29644966 | 0.85 | ALDH1A1 (0.47) | POLBALDH1A1MAPTPKMMAPK1 | |
| SCHEMBL12589615 | 0.85 | ALDH1A1 (0.47) | POLBALDH1A1MAPTPKMMAPK1 | |
| SCHEMBL5425892 | 0.85 | MAOA (0.50) | POLBCA1CA2ALDH1A1CA12 | |
| SCHEMBL5425889 | 0.85 | MAOA (0.50) | POLBCA1CA2ALDH1A1CA12 | |
| SCHEMBL4995638 | 0.84 | CA1 (0.57) | POLBCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-23 | — | — | US | disclosed |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-07-03 | — | — | US | disclosed |
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-23 | — | — | US | disclosed |
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-23 | — | — | US | disclosed |
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |
| WO-2010075286-A1 | MOLECULAR ACTIVATORS OF THE Wnt/β-CATENIN PATHWAY | UNIVERSITY OF WASHINGTON (US) | 2010-07-01 | — | — | WO | disclosed |
| EP-1975620-A2 | Three hybrid assay system | GPC Biotech AG (DE) | 2008-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | POLB 2990/4885CA1 2849/4885CA2 855/4885 |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | POLB 2990/4885CA1 2849/4885CA2 855/4885 |
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | POLB 2990/4885CA1 2849/4885CA2 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.