Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834560 | 0.91 | SLC6A4 (0.54) | SLC6A4HTR1A | |
| SCHEMBL4834380 | 0.88 | SLC6A4 (0.50) | SLC6A4MPOHTR1A | |
| SCHEMBL4838168 | 0.87 | SLC6A4 (0.49) | SLC6A4MPOHTR1A | |
| SCHEMBL4834686 | 0.85 | SLC6A4 (0.52) | SLC6A4MPOHTR1A | |
| SCHEMBL4834807 | 0.85 | SLC6A4 (0.49) | SLC6A4MPOHTR1A | |
| SCHEMBL4841807 | 0.85 | SLC6A4 (0.52) | SLC6A4MPOHTR1A | |
| SCHEMBL4830814 | 0.83 | SLC6A4 (0.49) | SLC6A4MPOHTR1A | |
| SCHEMBL4841842 | 0.82 | SLC6A4 (0.49) | SLC6A4MPOHTR1A | |
| SCHEMBL4830718 | 0.82 | SLC6A4 (0.51) | SLC6A4MPOHTR1A | |
| SCHEMBL4840462 | 0.81 | SLC6A4 (0.46) | SLC6A4MPOHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432282-B2 | Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-10-07 | — | — | US | claimed |
| EP-1562596-B1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2006-08-30 | — | — | EP | claimed |
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | MERCK PATENT GMBH (DE) | 2006-03-23 | — | — | US | claimed |
| CN-1708303-A | pyridylalkyl-aminoalkyl-1H-indole derivatives as antidepressants and anxiolytics having 5-HT and serotonin reuptake inhibition | MERCK PATENT GMBH (DE) | 2005-12-14 | — | — | CN | claimed |
| US-7432282-B2 | Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-10-07 | — | — | US | disclosed |
| EP-1562596-B1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2006-08-30 | — | — | EP | disclosed |
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | MERCK PATENT GMBH (DE) | 2006-03-23 | — | — | US | disclosed |
| CN-1708303-A | pyridylalkyl-aminoalkyl-1H-indole derivatives as antidepressants and anxiolytics having 5-HT and serotonin reuptake inhibition | MERCK PATENT GMBH (DE) | 2005-12-14 | — | — | CN | disclosed |
| EP-1562596-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GmbH (DE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004047840-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | HTR1A, HTR1D, HTR1E | SLC6A4 22/4885MPO 4402/4885HTR1A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.