Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14052229 | 1.00 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL21059214 | 1.00 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL7924710 | 1.00 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL21059194 | 0.98 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL10192215 | 0.94 | RAB9A (0.70) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL12411578 | 0.94 | RAB9A (0.69) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL13931799 | 0.93 | TSHR (0.56) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL13931804 | 0.93 | TSHR (0.56) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL13931805 | 0.93 | TSHR (0.56) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL12723978 | 0.92 | TSHR (0.67) | NPC1RAB9ASMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110903259-B | Process for efficiently synthesizing Cetilistat by taking 2-amino-5-methylbenzoic acid as raw material | 合肥工业大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-110903259-A | Process for efficiently synthesizing Cetilistat by taking 2-amino-5-methylbenzoic acid as raw material | 合肥工业大学 | 2020-03-24 | — | — | CN | disclosed |
| CN-105622538-B | One kettle way prepares Cetilistat in high yield | 中国医学科学院药物研究所 | 2019-02-01 | — | — | CN | disclosed |
| WO-2018011676-A1 | NOVEL PROCESSES FOR THE PREPARATION OF 2-OXY-BENZOXAZINONE DERIVATIVES | SYMED LABS LIMITED (IN) | 2018-01-18 | — | — | WO | disclosed |
| WO-2018011676-A1 | NOVEL PROCESSES FOR THE PREPARATION OF 2-OXY-BENZOXAZINONE DERIVATIVES | SYMED LABS LIMITED (IN) | 2018-01-18 | — | — | WO | disclosed |
| CN-105669585-A | Preparation method of cetilistat | 北京修正创新药物研究院有限公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-105622538-A | One-pot high-yielding preparation of cetilistat | INST MATERIA MEDICA CAMS | 2016-06-01 | — | — | CN | disclosed |
| CN-103936687-B | A kind of west of preparing is for the method for Li Sita | CHONGQING TOPTECH PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2016-03-30 | — | — | CN | disclosed |
| CN-103936687-A | Method for preparing cetilistat | CHONGQING TOPTECH PHARMACEUTICAL TECHNOLOGY CO LTD | 2014-07-23 | — | — | CN | disclosed |
| US-20080171891-A1 | Process for preparing carbamic ester derivatives | HOLZER BETTINA | 2008-07-17 | — | — | US | disclosed |
| US-20080171891-A1 | Process for preparing carbamic ester derivatives | HOLZER BETTINA | 2008-07-17 | — | — | US | disclosed |
| US-7396952-B2 | Process for preparing carbamic ester derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2008-07-08 | — | — | US | disclosed |
| US-7396952-B2 | Process for preparing carbamic ester derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2008-07-08 | — | — | US | disclosed |
| US-20070232825-A1 | Process for preparing carbamic ester derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20070232825-A1 | Process for preparing carbamic ester derivatives | LANXESS DEUTSCHLAND GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| CN-1295677-A | Method and apparatus for accelerated orthokeratology | EASTA PHARMACEUTICALS INC (US) | 2001-05-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171891-A1 | Process for preparing carbamic ester derivatives | CPS1, CA7, CA4 | NPC1 1638/4885RAB9A 1332/4885SMN1; SMN2 1792/4885 |
| US-20070232825-A1 | Process for preparing carbamic ester derivatives | CPS1, CA7, CA4 | NPC1 1638/4885RAB9A 1332/4885SMN1; SMN2 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.