Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 13/20 | 1.00 |
| ▸ | FAAH | O00519 | 8/20 | 1.00 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838333 | 0.94 | CES1 (1.00) | CES1FAAHNCEH1ALDH1A1GAA | |
| SCHEMBL4841486 | 0.88 | CES1 (1.00) | CES1FAAHNCEH1DAGLA | |
| SCHEMBL4839586 | 0.88 | CES1 (1.00) | CES1FAAHNCEH1DAGLA | |
| SCHEMBL15503837 | 0.83 | CES1 (0.79) | CES1FAAHNCEH1ALDH1A1GAA | |
| SCHEMBL4836309 | 0.82 | CES1 (1.00) | CES1FAAHNCEH1DAGLA | |
| SCHEMBL2163056 | 0.82 | CES1 (1.00) | CES1FAAHNCEH1DAGLA | |
| SCHEMBL4831663 | 0.82 | CES1 (1.00) | CES1FAAHNCEH1DAGLA | |
| SCHEMBL4837702 | 0.82 | CES1 (1.00) | CES1FAAHNCEH1DAGLA | |
| SCHEMBL2162221 | 0.81 | CES1 (0.72) | CES1FAAHNCEH1DAGLA | |
| SCHEMBL12398543 | 0.80 | CES1 (1.00) | CES1FAAHNCEH1DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096931-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-24 | — | — | US | claimed |
| US-7351724-B2 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-01 | — | — | US | claimed |
| EP-1812427-A1 | OXADIAZOLE KETONE INHIBITORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2007-08-01 | — | — | EP | claimed |
| US-20060100212-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-05-11 | — | — | US | claimed |
| WO-2006044617-A1 | OXADIAZOLE KETONE INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-04-27 | — | — | WO | claimed |
| US-20080096931-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096931-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-24 | — | — | US | disclosed |
| US-20080096931-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-24 | — | — | US | disclosed |
| US-7351724-B2 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-01 | — | — | US | disclosed |
| US-7351724-B2 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-01 | — | — | US | disclosed |
| US-7351724-B2 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-04-01 | — | — | US | disclosed |
| EP-1812427-A1 | OXADIAZOLE KETONE INHIBITORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060100212-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-05-11 | — | — | US | disclosed |
| WO-2006044617-A1 | OXADIAZOLE KETONE INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100212-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | FAAH, FAAH2, HCRTR2 | CES1 60/4885FAAH 1/4885NCEH1 22/4885 |
| US-20080096931-A1 | Oxadiazole ketone inhibitors of fatty acid amide hydrolase | FAAH, FAAH2, HCRTR2 | CES1 60/4885FAAH 1/4885NCEH1 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.