SCHEMBL48416

SCHEMBL48416

CCOCCn1cnc2nc(N)[nH]c(=O)c21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.45
ADORA2B P29275 1/20 0.45
POLB P06746 2/20 0.44
PNP P00491 2/20 0.43
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
EDNRA P25101 1/20 0.43
HTR2A P28223 1/20 0.43
RECQL P46063 1/20 0.43
BLM P54132 1/20 0.43
HBB P68871 1/20 0.43
HSD17B10 Q99714 1/20 0.43
HPRT1 P00492 5/20 0.43
POLA1 P09884 1/20 0.43
POLG P54098 1/20 0.43
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
PDE4C Q08493 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27710751 0.86 ADORA2A (0.52) ADORA2AADORA2BALDH1A1PDE4APDE4B
SCHEMBL29286377 0.86 TK1 (0.46) PNPUSP2TSHREDNRAHTR2A
SCHEMBL4592790 0.83 ADORA2A (0.47) ADORA2APNPUSP2TSHREDNRA
SCHEMBL48223 0.81 PNP (0.42) ADORA2BPNPUSP2TSHREDNRA
SCHEMBL48362 0.81 TK1 (0.51) ADORA2BPNPUSP2TSHREDNRA
SCHEMBL28712711 0.79 PNP (0.42) PNPUSP2TSHREDNRAHTR2A
SCHEMBL8171883 0.78 TK1 (0.45) ADORA2BPNPUSP2TSHREDNRA
SCHEMBL6703317 0.78 PNP (0.51) POLBPNPUSP2TSHREDNRA
SCHEMBL6691912 0.78 PNP (0.67) POLBPNPUSP2TSHREDNRA
SCHEMBL1665132 0.77 TK1 (0.47) PNPUSP2TSHREDNRAHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735621-A1 NUCLEIC ACID SYNTHESIS ON REUSABLE SUPPORT DNA Script (FR) 2026-05-06 EP disclosed
EP-4665866-A1 REAGENTS AND METHODS FOR NORMALIZATION Twist Bioscience Corporation (US) 2025-12-24 EP disclosed
US-20250369027-A1 SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS TWIST BIOSCIENCE CORP (US) 2025-12-04 US disclosed
EP-4655411-A2 ENZYMATIC SYNTHESIS OF POLYNUCLEOTIDE PROBES DNA Script (FR) 2025-12-03 EP disclosed
US-12421628-B2 Massively parallel enzymatic synthesis of nucleic acid strands DNA SCRIPT (FR) 2025-09-23 US disclosed
US-20250215617-A1 MASSIVELY PARALLEL ENZYMATIC SYNTHESIS OF NUCLEIC ACID STRANDS DNA SCRIPT (FR) 2025-07-03 US disclosed
CN-119677866-A Substrate cleavage for nucleic acid synthesis 特韦斯特生物科学公司 2025-03-21 CN disclosed
EP-4504959-A1 SUBSTRATE CLEAVAGE FOR NUCLEIC ACID SYNTHESIS Twist Bioscience Corporation (US) 2025-02-12 EP disclosed
WO-2025003434-A1 NUCLEIC ACID SYNTHESIS ON REUSABLE SUPPORT DNA SCRIPT (FR) 2025-01-02 WO disclosed
US-20240384319-A1 Synthesis of Oligonucleotides THE UNIVERSITY OF MANCHESTER (GB) 2024-11-21 US disclosed
US-20210332351-A1 Massively Parallel Enzymatic Synthesis of Nucleic Acid Strands DNA SCRIPT (FR) 2021-10-28 US disclosed
CN-113272442-A One-pot synthesis of pools of oligonucleotides DNA斯克瑞普特公司 2021-08-17 CN disclosed
CN-113056327-A Massively parallel enzymatic synthesis of nucleic acid strands DNA斯克瑞普特公司 2021-06-29 CN disclosed
EP-3826762-A1 MASSIVELY PARALLEL ENZYMATIC SYNTHESIS OF NUCLEIC ACID STRANDS DNA Script (FR) 2021-06-02 EP disclosed
WO-2020141143-A1 ONE POT SYNTHESIS OF SETS OF OLIGONUCLEOTIDES DNA SCRIPT (FR) 2020-07-09 WO disclosed
WO-2020020608-A1 MASSIVELY PARALLEL ENZYMATIC SYNTHESIS OF NUCLEIC ACID STRANDS DNA SCRIPT (FR) 2020-01-30 WO disclosed
EP-2028272-B1 METHOD OF MODIFYING NUCLEOTIDE CHAIN PANASONIC CORP (JP) 2014-01-08 EP disclosed
EP-1647592-B1 METHOD OF MODIFYING NUCLEOTIDE CHAIN PANASONIC CORP (JP) 2009-03-11 EP disclosed
EP-2028272-A1 METHOD OF MODIFYING NUCLEOTIDE CHAIN Panasonic Corporation (JP) 2009-02-25 EP disclosed
EP-1647592-A1 METHOD OF MODIFYING NUCLEOTIDE CHAIN MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) 2006-04-19 EP disclosed