Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841809 | 1.00 | KDM4E (0.46) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL8778837 | 0.76 | CES2 (0.50) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL1314838 | 0.76 | CES2 (0.50) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL29692098 | 0.76 | CES2 (0.50) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL31204160 | 0.76 | CES2 (0.50) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL1314837 | 0.76 | CES2 (0.50) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL28147978 | 0.76 | KDM4E (0.45) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL5075064 | 0.75 | KDM4E (0.50) | KDM4EHPGDALDH1A1KMT2ANPC1 | |
| SCHEMBL2119207 | 0.74 | ALDH1A1 (0.56) | HPGDALDH1A1KMT2ANPC1MEN1 | |
| SCHEMBL406589 | 0.74 | TSHR (0.39) | HPGDNPC1SMN1; SMN2TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1484325-B1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-7453001-B2 | Such as, ethyl 3-(2-hydroxyphenyl)-6-methyl4-oxo4,5,6,7-tetrahydrobenzo[d]isoxazole-5-carboxylate; intermediates | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-11-18 | — | — | US | disclosed |
| US-7342036-B2 | Isoxazole derivatives and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20080058530-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-06 | — | — | US | disclosed |
| US-20050026978-A1 | Isoxazole derivatives and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2005-02-03 | — | — | US | disclosed |
| EP-1484325-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Japan Science and Technology Agency (JP) | 2004-12-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026978-A1 | Isoxazole derivatives and process for producing the same | CYP1A1, CYP1A2, CYP2E1 | KDM4E 3642/4885HPGD 640/4885ALDH1A1 67/4885 |
| US-20080058530-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | CYP1A1, CYP1A2, CYP2E1 | KDM4E 3642/4885HPGD 640/4885ALDH1A1 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.