Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483518 | 1.00 | YAP1 (0.45) | YAP1PRMT5TP53KCNH2MAOB | |
| Ethane SCHEMBL483694 | 1.00 | YAP1 (0.45) | YAP1PRMT5TP53KCNH2MAOB | |
| SCHEMBL483558 | 1.00 | YAP1 (0.45) | YAP1PRMT5TP53KCNH2MAOB | |
| SCHEMBL483557 | 1.00 | YAP1 (0.45) | YAP1PRMT5TP53KCNH2MAOB | |
| SCHEMBL1104528 | 0.92 | YAP1 (0.48) | YAP1PRMT5TP53KCNH2MAOB | |
| SCHEMBL484710 | 0.92 | YAP1 (0.46) | YAP1PRMT5TP53KCNH2MAOB | |
| SCHEMBL311656 | 0.92 | YAP1 (0.46) | YAP1PRMT5TP53KCNH2MAOB | |
| SCHEMBL1104539 | 0.90 | YAP1 (0.44) | YAP1PRMT5TP53KCNH2ADAM17 | |
| SCHEMBL483409 | 0.89 | KCNH2 (0.46) | YAP1PRMT5KCNH2MAOBGHSR | |
| SCHEMBL483695 | 0.88 | KCNH2 (0.51) | KCNH2MAOBADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |