Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 2/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483557 | 0.89 | YAP1 (0.45) | KCNH2MAOBGHSRYAP1PRMT5 | |
| SCHEMBL484203 | 0.89 | YAP1 (0.45) | KCNH2MAOBGHSRYAP1PRMT5 | |
| SCHEMBL483518 | 0.89 | YAP1 (0.45) | KCNH2MAOBGHSRYAP1PRMT5 | |
| SCHEMBL483558 | 0.89 | YAP1 (0.45) | KCNH2MAOBGHSRYAP1PRMT5 | |
| Ethane SCHEMBL483694 | 0.89 | YAP1 (0.45) | KCNH2MAOBGHSRYAP1PRMT5 | |
| SCHEMBL10167536 | 0.84 | YAP1 (0.42) | KCNH2GHSRLMNAYAP1MDM4 | |
| SCHEMBL5152764 | 0.84 | GPR119 (0.44) | — | |
| SCHEMBL1104540 | 0.82 | YAP1 (0.41) | KCNH2MAOBGHSRLMNAYAP1 | |
| SCHEMBL484710 | 0.82 | YAP1 (0.46) | KCNH2MAOBGHSRYAP1PRMT5 | |
| SCHEMBL311656 | 0.82 | YAP1 (0.46) | KCNH2MAOBGHSRYAP1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153623-B2 | Compounds | Convergence Pharmaceuticals Limited (GB) | 2012-04-10 | — | — | US | disclosed |
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |
| EP-1943216-A1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007042250-A1 | PROLINAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |