Sugi Predict

Sugi Predict / Compounds / SCHEMBL4842377

SCHEMBL4842377

SCHEMBL4842377

CC1(c2ccc(Cl)cc2)OC(=O)Nc2ccc([N+](=O)[O-])cc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 9/20 0.49
▸ ACHE P22303 1/20 0.44
▸ ALPL P05186 1/20 0.42
▸ AKR1B1 P15121 1/20 0.42
▸ NR3C1 P04150 1/20 0.40
▸ NR3C2 P08235 1/20 0.40
▸ AR P10275 1/20 0.40
▸ CAPN9 O14815 1/20 0.39
▸ CASP3 P42574 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ CYP2C9 P11712 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ MEN1 O00255 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ PKM P14618 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4841848 0.78 PGR (0.62) PGRALPLAKR1B1NR3C1NR3C2
SCHEMBL4841973 0.78 HTT (0.36) PGRMEN1NPC1POLBMAPT
SCHEMBL4841787 0.77 PGR (0.50) PGRNR3C1NR3C2ARALDH1A1
SCHEMBL4842594 0.77 PGR (0.47) PGRCASP3ALDH1A1NPC1MDM2
SCHEMBL4845321 0.74 PGR (0.57) PGRALPLAKR1B1CAPN9CASP3
SCHEMBL3380558 0.73 ALPL (0.47) PGRALPLAKR1B1CAPN9CASP3
SCHEMBL3871904 0.69 PGR (0.74) PGRNR3C1NR3C2AR
SCHEMBL11440857 0.68 AKR1B1 (0.53) PGRACHEALPLAKR1B1CAPN9
SCHEMBL31251189 0.68 PGR (0.71) PGRACHEALPLAKR1B1CAPN9
SCHEMBL1841727 0.68 PGR (0.71) PGRACHEALPLAKR1B1CAPN9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7354915-B2 6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2008-04-08 — — US disclosed
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-09-27 — — US disclosed
US-7247625-B2 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-07-24 — — US disclosed
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH 2005-04-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 PGR 1/4885ACHE 4602/4885ALPL 4570/4885
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 PGR 1/4885ACHE 4602/4885ALPL 4570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.