Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.46 |
| ▸ | MDH1 | P40925 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842404 | 1.00 | PLK1 (0.47) | PLK1PLK3MDH1NR1H4KCNA5 | |
| SCHEMBL4844205 | 0.99 | PLK1 (0.46) | PLK1PLK3MDH1NR1H4KCNA5 | |
| SCHEMBL4844194 | 0.99 | PLK1 (0.46) | PLK1PLK3MDH1NR1H4KCNA5 | |
| SCHEMBL4837689 | 0.97 | PLK1 (0.43) | PLK1PLK3MDH1NR1H4KCNA5 | |
| SCHEMBL4837674 | 0.97 | PLK1 (0.43) | PLK1PLK3MDH1NR1H4KCNA5 | |
| SCHEMBL4844038 | 0.94 | ABCG2 (0.45) | NR1H4KCNA5NPC1RAB9AALDH1A1 | |
| SCHEMBL4844026 | 0.94 | ABCG2 (0.45) | NR1H4KCNA5NPC1RAB9AALDH1A1 | |
| SCHEMBL4844736 | 0.92 | PLK1 (0.48) | PLK1PLK3KCNA5TRPV1CFTR | |
| SCHEMBL4844715 | 0.92 | PLK1 (0.48) | PLK1PLK3KCNA5TRPV1CFTR | |
| SCHEMBL4835246 | 0.92 | NR1H4 (0.54) | NR1H4NPC1RAB9AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378428-B2 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-27 | — | — | US | disclosed |
| US-20050222138-A1 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222138-A1 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | PARK7, MMP8, CDK7 | PLK1 541/4885PLK3 2079/4885MDH1 1881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.