Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 7/20 | 0.70 |
| ▸ | RAB9A | P51151 | 7/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | CASP3 | P42574 | 1/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.69 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4850039 | 0.85 | NPC1 (0.70) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4602494 | 0.83 | NPC1 (1.00) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30116088 | 0.82 | NPC1 (0.68) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30195363 | 0.82 | NPC1 (1.00) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1821021 | 0.82 | NPC1 (1.00) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5016980 | 0.81 | NPC1 (0.68) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1820740 | 0.81 | NPC1 (0.77) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1752748 | 0.80 | NPC1 (0.75) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5017000 | 0.80 | NPC1 (0.75) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1304004 | 0.80 | NPC1 (0.75) | PIK3CGNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390907-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20050153984-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153984-A1 | Vanilloid receptor ligands and their use in treatments | TRPV1, TRPV2, TRPV3 | PIK3CG 2234/4885NPC1 2938/4885RAB9A 1396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.