Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5471374 | 0.82 | KDM5B (0.75) | NOS2KDM5AKDM4CKDM5BMEN1 | |
| SCHEMBL12583544 | 0.81 | NPC1 (0.51) | KDM5AKDM4CKDM5BRAB9AGAA | |
| SCHEMBL3492541 | 0.81 | MAPT (0.66) | SMN1; SMN2RAB9AMEN1KMT2AGAA | |
| SCHEMBL1568064 | 0.81 | RAB9A (0.59) | SMN1; SMN2RAB9ACYP1A2GAAMAPT | |
| SCHEMBL11562643 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2NPSR1RAB9AALOX15MEN1 | |
| SCHEMBL31026203 | 0.80 | MMP13 (0.56) | SMN1; SMN2RAB9AMEN1KMT2ACYP1A2 | |
| SCHEMBL12852738 | 0.79 | JMJD6 (0.53) | SMN1; SMN2KDM5AKDM4CKDM5BRAB9A | |
| SCHEMBL31141689 | 0.79 | NPSR1 (0.68) | SMN1; SMN2NPSR1RAB9AMEN1KMT2A | |
| SCHEMBL2475428 | 0.78 | JMJD6 (0.52) | SMN1; SMN2KDM5AKDM4CKDM5BRAB9A | |
| SCHEMBL10106419 | 0.77 | MAPT (0.65) | SMN1; SMN2RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991227-A2 | PROLYL HYDROXYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007103905-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |