Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | APOB | P04114 | 1/20 | 0.35 |
| ▸ | MTTP | P55157 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4913354 | 0.88 | TBXA2R (0.39) | TBXA2REPHX2NR1H2 | |
| SCHEMBL4785715 | 0.87 | TBXA2R (0.40) | TBXA2RNR1H2GRIA2APOBMTTP | |
| SCHEMBL4781127 | 0.81 | NR1H2 (0.51) | TBXA2REPHX2NR1H2GRIA2APOB | |
| SCHEMBL4782109 | 0.80 | NR1H2 (0.42) | TBXA2RNR1H2GRIA2DNMT1CASP6 | |
| SCHEMBL4838056 | 0.79 | CA1 (0.45) | NR1H2L3MBTL1ALDH1A1APOBMTTP | |
| SCHEMBL4845688 | 0.79 | NR1H2 (0.38) | NR1H2NR1H3 | |
| SCHEMBL4844918 | 0.78 | NR1H2 (0.39) | NR1H2NR1H3 | |
| SCHEMBL4911955 | 0.78 | KDM4E (0.43) | NR1H2TDP1L3MBTL1ALDH1A1CYP26B1 | |
| SCHEMBL4900753 | 0.78 | KDM4E (0.43) | NR1H2TDP1L3MBTL1ALDH1A1CYP26B1 | |
| SCHEMBL4783715 | 0.77 | NR1H2 (0.46) | TBXA2RNR1H2GRIA2APOBMTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |